Coagulation factor VIIa injection

Coagulation factor VIIa is injected into a vein through an IV. A healthcare provider will give you this injection.

You may need frequent medical tests to help your doctor determine how long to treat you with coagulation factor VIIa.

Wear a medical alert tag or carry an ID card stating that you have a bleeding disorder in case of emergency. Any medical care provider who treats you should know that you are using coagulation factor VIIa.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Applies to coagulation factor viia: intravenous powder for solution

Along with its needed effects, coagulation factor viia may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking coagulation factor viia:

• Bleeding problems
• fever
• high blood pressure
• joint or muscle pain or stiffness

• Bloating or swelling of the face, hands, lower legs, or feet
• bluish color of the hands or feet
• blurred vision
• changes in facial color
• chest pain
• chills
• cold sweats
• confusion
• continuing thirst
• cough
• dizziness
• excessive sweating
• faintness
• fast heartbeat
• hives, itching, or skin rash
• large flat blue or purplish patches on the skin
• lightheadedness when getting up suddenly from a lying or sitting position
• persistent bleeding or oozing from puncture sites or mucous membranes (bowel, mouth, nose, or urinary bladder)
• puffiness or swelling of the eyelids or around the eyes
• shakiness
• slow or irregular heartbeat (less than 50 beats per minute)
• slurred speech
• sneezing
• sore throat
• sudden decrease in the amount of urine
• swelling of the face, fingers, feet, or lower legs
• troubled breathing, tightness in the chest
• unusual tiredness or weakness
• unusual weight gain

Some side effects of coagulation factor viia may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Burning or stinging at the injection site
• drowsiness
• feeling of warmth
• headache
• nausea or vomiting
• pinpoint red or purple spots on the skin
• redness of the face, neck, arms and occasionally, upper chest

CONGENITAL HEMOPHILIA A OR B WITH INHIBITORS:
Hemostatic:
90 mcg/kg IV bolus injection once every 2 hours (adjustable based on bleeding severity) until hemostasis is achieved or treatment is deemed inadequate

Post-hemostatic:
90 mcg/kg IV bolus injection once every 3 to 6 hours for severe bleeds

Perioperative Management:
Initial: 90 mcg/kg IV bolus injection once immediately before surgery; repeat every 2 hours for surgery duration (additional bolus doses may be required with major surgery).
Post-surgical:
-Minor surgery: 90 mcg/kg IV bolus injection once every 2 hours for 48 hours, then every 2 to 6 hours until healing occurs.
-Major surgery: 90 mcg/kg IV bolus injection once every 2 hours for 5 days, then every 4 hours until healing occurs.

ACQUIRED HEMOPHILIA:
Non-perioperative Management:
70 to 90 mcg/kg IV bolus injection once every 2 to 3 hours until hemostasis is achieved

Perioperative Management:
70 to 90 mcg/kg IV bolus injection once immediately before surgery; repeat every 2 to 3 hours for surgery duration and until hemostasis is achieved.

15 to 30 mcg/kg IV bolus injection once every 4 to 6 hours until hemostasis is achieved

Comments: Doses as low as 10 mcg/kg have been effective.

CONGENITAL HEMOPHILIA A OR B WITH INHIBITORS:
Hemostatic:
90 mcg/kg IV bolus injection once every 2 hours (adjustable based on bleeding severity) until hemostasis is achieved or treatment is deemed inadequate

Post-hemostatic:
90 mcg/kg IV bolus injection once every 3 to 6 hours for severe bleeds

Perioperative Management:
Initial: 90 mcg/kg IV bolus injection once immediately before surgery; repeat every 2 hours for surgery duration (additional bolus doses may be required with major surgery).
Post-surgical:
-Minor surgery: 90 mcg/kg IV bolus injection once every 2 hours for 48 hours, then every 2 to 6 hours until healing occurs.
-Major surgery: 90 mcg/kg IV bolus injection once every 2 hours for 5 days, then every 4 hours until healing occurs.

ACQUIRED HEMOPHILIA:
Non-perioperative Management:
70 to 90 mcg/kg IV bolus injection once every 2 to 3 hours until hemostasis is achieved

Perioperative Management:
70 to 90 mcg/kg IV bolus injection once immediately before surgery; repeat every 2 to 3 hours for surgery duration and until hemostasis is achieved.

Non-perioperative Management:
90 mcg/kg IV bolus injection once every 2 to 6 hours until hemostasis is achieved in severe bleeding episodes requiring systemic hemostatic therapy

Perioperative Management:
Initial: 90 mcg/kg IV bolus injection immediately before surgery; repeat every 2 hours for procedure duration.
Post-surgical: 90 mcg/kg IV bolus injection once every 2 to 6 hours

Data not available