Codeine and Chlorpheniramine

Name: Codeine and Chlorpheniramine

Codeine and chlorpheniramine Drug Class

Codeine and chlorpheniramine is part of the drug class:

  • OTHER COLD PREPARATIONS

Pharmacologic Category

  • Analgesic, Opioid
  • Antitussive
  • Histamine H1 Antagonist
  • Histamine H1 Antagonist, First Generation

Pharmacology

Codeine: Binds to opioid receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain; causes cough suppression by direct central action in the medulla; produces generalized CNS depression.

Chlorpheniramine: H1 receptor antagonist that also possesses anticholinergic and sedative activity. It prevents released histamine from dilating capillaries and causing edema of the respiratory mucosa.

Use Labeled Indications

Cough and upper respiratory allergy symptoms: Relief of cough and symptoms associated with upper respiratory allergies or a common cold in adults ≥18 years.

Dosing Geriatric

Refer to adult dosing.

Storage

Store at 20ºC to 25ºC (68ºF to 77ºF); excursions permitted from 15ºC to 30ºC (59ºF to 86ºF). Protect from light.

ALERT U.S. Boxed Warning

Death related to ultra-rapid metabolism of codeine to morphine:

Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.

Risk from concomitant use with benzodiazepines or other CNS depressants:

Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol.

Monitoring Parameters

Relief of cough and allergy symptoms.

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