Colchicine and probenecid

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Avoid drinking alcohol, which can raise uric acid levels in your blood and may also increase your risk of stomach problems caused by colchicine and probenecid.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have:

• painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;

• fever, severe muscle weakness, mood changes, seizure (convulsions);

• easy bruising or bleeding, unusual weakness; or

• severe diarrhea, nausea, vomiting, or stomach pain.

Common side effects may include:

• mild nausea or stomach pain, loss of appetite;

• headache;

• dizziness;

• hair loss; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may interact with colchicine and probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Anti-inflammatory Agent
• Antigout Agent
• Uricosuric Agent

Do not initiate therapy until acute attack has subsided.

See individual agents.

CBC, renal function, serum uric acid, urinary uric acid, frequency of gout attacks (Khanna 2012).

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience dizziness, headache, flushing, lack of appetite, or hair loss. Have patient report immediately to prescriber signs of infection, signs of liver problems (dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or jaundice), burning or numbness feeling, severe nausea, vomiting, severe diarrhea, signs of a kidney stone (back pain, abdominal pain, or hematuria), urinary retention, change in amount of urine passed, bruising, bleeding, severe loss of strength and energy, pale skin, muscle pain, or muscle weakness (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.