Collagenase (Topical)

Use collagenase as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Do not take this medicine by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
• Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
• Clean affected part before use. Make sure to dry well.
• Put a thin layer on the affected part.
• Avoid putting on healthy skin.

What do I do if I miss a dose?

• Put on a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not put on 2 doses or extra doses.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Store at room temperature.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about collagenase, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about collagenase. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using collagenase.

Review Date: October 4, 2017

There are no dosage adjustments provided in the manufacturer’s labeling; it is not known if collagenase is absorbed systemically following topical application.

Signs and symptoms of systemic bacterial infection

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions, and if you are pregnant or breast-feeding.

Apply this medication only to the affected skin wound. Try not to get any ointment on the healthy skin around the wound.

The enzymes in collagenase topical may increase your risk of a bacterial infection in your blood stream. Call your doctor at once if you have any signs of infection such as fever, chills, rapid heartbeats, nausea, vomiting, stomach pain, or feeling very ill.

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions.

It is not known whether collagenase topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether collagenase topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of collagenase topical is not expected to be dangerous. If you think you have applied too much of this medication, you may wash off the enzyme with povidone iodine.

Avoid using other medications on the areas you treat with collagenase topical unless your doctor tells you to.