Clonidine/chlorthalidone

Contraindications

Hypersensitivity to either component or sulfonamide derivatives

Cautions

Bronchospastic disease

DM, hyperuricemia or gout, hypotension, SLE

Chlorthalidone may cause fluid or electrolyte imbalance including hyponatremia, hypochloremic alkalosis, or hypokalemia

History of depression

Liver disease

May aggravate digitalis toxicity

Patients allergic to sulfa may show cross-sensitivity

May impair ability to perform hazarous tasks

Risk of male sexual dysfunction

Renal impairment

Severe coronary insufficiency, recent MI, conduction disturbances, cerebrovascular disease, chronic renal failure, Raynaud's disease, thromboangiitis obliteran

Sudden cessation of clonidine treatment has resulted in subjective symptoms such as nervousness, agitation and headache, accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma

Pregnancy Category: C

Lactation: excreted in breast milk, use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.