Clindamycin and Tretinoin

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• Do not put on sunburned skin.
• Do not put on cuts, scrapes, or damaged skin.
• Skin may look worse before it looks better.
• It may take several weeks to see the full effects.
• Use other pimple (acne) drugs with care. More skin irritation may happen.
• Talk with your doctor before you use other drugs or products on your skin.
• Practice good skin care and avoid the sun.
• You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• Some weather conditions may irritate the skin. Talk with the doctor.
• Diarrhea, bloody diarrhea, and a certain bowel problem (colitis) have happened with clindamycin and tretinoin. Very bad colitis may lead to death. Call your doctor right away if you have stomach pain or cramps, very bad or watery diarrhea, or bloody diarrhea. Do not try to treat diarrhea without first checking with your doctor.
• It is common to have skin irritation with this medicine. These reactions may include burning, dry skin, itching, peeling, redness, and scaling. Call your doctor if you have skin irritation that is very bad, bothers you, or does not go away.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using clindamycin and tretinoin while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Do not take clindamycin and tretinoin by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
• Put on at bedtime.
• Wash your hands before and after use.
• Clean affected part before use. Make sure to dry well.
• Put a thin layer on the affected skin and rub in gently.
• To gain the most benefit, do not miss doses.

What do I do if I miss a dose?

• Put on a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not put on 2 doses or extra doses.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

• Veltin
• Ziana

Regional enteritis, ulcerative colitis, history of antibiotic-associated colitis

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

For external use only. Not for ophthalmic, oral, or intravaginal use. Prior to application, gently wash face with a mild soap and pat dry. Apply in the evening or at bedtime. Apply a pea-size amount to one fingertip and then dotted on chin, cheeks, nose, and forehead. Avoid contact with sunburned skin. Gently rub over entire face or entire affected area while avoiding eyes, mouth, angles of nose, and mucous membranes.

Frequency not defined.

>10%: Dermatologic: Burning sensation of skin, desquamation, erythema, xeroderma

1% to 10%:

Dermatologic: Dermatitis, pruritus, skin irritation, stinging of the skin, sunburn

Gastrointestinal: Gastrointestinal symptoms (unspecified)

Respiratory: Nasopharyngitis