Clinsol

Oral:

Serious side effects have been reported with oral clindamycin including the following:

• Abdominal pain
• Gastrointestinal upset
• Pain or difficulty when swallowing
• White patches in the mouth
• Blisters
• Rash
• Hives
• Yellowing of the skin or eyes
• Decreased urination

Topical:

Serious side effects have been reported with topical clindamycin including the following:

• Dry, itching, burning, or peeling skin
• Headache
• Diarrhea
• Abdominal pain or gastrointestinal upset
• Thick, white discharge or burning, itching, or swelling of the vagina with use of vaginal clindamycin products

Injectable:

Serious side effects have been reported with injectable clindamycin including the following:

• Abdominal pain
• Gastrointestinal upset
• Pain or difficulty when swallowing
• White patches in the mouth
• Blisters
• Rash
• Hives
• Yellowing of the skin or eyes
• Decreased urination

Do not take clindamycin if you:

• are allergic to clindamycin or to any of its ingredients
• are allergic to lincomycin (Lincocin)

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Clindamycin falls into category B. There are no well-done studies that have been done in humans with clindamycin. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Absorption

Clindamycin hydrochloride is rapidly absorbed from the canine and feline gastrointestinal tract.

Dog Serum Levels

Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 12 hours. This same study revealed that average peak serum concentrations of clindamycin occur 1 hour and 15 minutes after oral dosing. The elimination half-life for clindamycin in dog serum was approximately 5 hours. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs.

Cat Serum Levels

Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 5 mg/lb of clindamycin hydrochloride liquid every 24 hours. The average peak serum concentration of clindamycin occurs approximately 1 hour after oral dosing. The elimination half-life of clindamycin in feline serum is approximately 7.5 hours. In healthy cats, minimal accumulation occurs after multiple oral doses of clindamycin hydrochloride, and steady-state should be achieved by the third dose.

Clinsol Liquid (for use in dogs and cats) is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below:

Dogs

Skin infections (wounds and abscesses) due to: coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium ecrophorum and Clostridium perfringens.

Dental infections due to Staphyloccus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.

Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium pefringens.

Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.

Cats

Skin infections (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis.

Dental infections due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis.

Dogs

Oral

2.5-15.0 mg/lb (1-6 mL/10 lbs) body weight every 12 hours.

Duration

Treatment with clindamycin hydrochloride may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen.

Dosage Schedule

Clinsol Liquid, administer 1-6 mL/10 pounds body weight every 12 hours.

Dogs

Oral

5.0-15.0 mg/lb (2-6 mL/10 lbs) body weight every 12 hours.

Duration

Treatment with clindamycin hydrochloride is recommended for a minimum of 28 days. Treatment should not be continued for longer than 28 days if no response to therapy is seen.

Dosage Schedule

Clinsol Liquid, administer 2-6 mL/10 pounds body weight every 12 hours.

Cats

5.0-15.0 mg/lb (1-3 mL/5 lbs) body weight once every 24 hours depending on the severity of the condition.

Duration

Treatment with clindamycin hydrochloride may be continued up to a maximum of 14 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three to four days if no clinical response to therapy is seen.

Dosage Schedule

Clinsol Liquid, to provide 5.0 mg/lb. administer 1 mL/5 lbs body weight once every 24 hours; to provide 15.0 mg/lb, administer 3 mL/5 lbs body weight once every 24 hours.