Clintabs

Absorption

Clindamycin hydrochloride is rapidly absorbed from the canine gastrointestinal tract.

Dog Serum Levels

Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 12 hours. This same study revealed that average peak serum concentrations of clindamycin occur 1 hour and 15 minutes after oral dosing. The elimination half-life for clindamycin in dog serum was approximately 5 hours. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs.

Rat and Dog Data

One year oral toxicity studies in rats and dogs at doses of 30, 100 and 300 mg/kg/day (13.6, 45.5 and 136.4 mg/lb/day) have shown clindamycin hydrochloride capsules to be well tolerated. Differences did not occur in the parameters evaluated to assess toxicity when comparing groups of treated animals with contemporary controls. Rats administered clindamycin hydrochloride at 600 mg/kg/day (272.7 mg/lb/day) for six months tolerated the drug well; however, dogs orally dosed at 600 mg/kg/day (272.7 mg/lb/day) vomited, had anorexia, and subsequently lost weight. At necropsy these dogs had erosive gastritis and focal areas of necrosis of the mucosa of the gallbladder.

Safety in gestating bitches or breeding males has not been established.

Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea.

To report adverse reactions or a suspected adverse reaction, call 1-800-338-3659.

Clintabs Tablets are available as:

ANADA #200-316, Approved by FDA

To report a suspected adverse reaction or to request a material safety data sheet (MSDS), call 1-800-338-3659.

Store at controlled room temperature 20° to 25° C (68° to 77° F) [see USP].

NDC-051311-400-40

Virbac
ANIMAL HEALTH

Clintabs® Tablets
clindamycin hydrochloride
25 mg tablets, USP

Equiv. to 25 mg clindamycin

For Use in Dogs Only

Caution: Federal (USA) law restricts this
drug to use by or on the order of
a licensed veterinarian.

ANADA # 200-316, Approved by FDA

400 Tablets