Bydureon (Exenatide Extended-Release Injection (Bydureon) (Pens))

• Tell all of your health care providers that you take Bydureon. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
• Wear disease medical alert ID (identification).
• Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
• Check your blood sugar as you have been told by your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• If you are taking warfarin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with Bydureon.
• It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.
• Talk with your doctor before you drink alcohol.
• Do not share with another person even if the needle has been changed. Sharing your tray or pen may pass infections from one person to another. This includes infections you may not know you have.
• Kidney problems have happened with this medicine. Some people have needed dialysis or a kidney transplant. Talk with the doctor.
• Very bad skin problems have happened where the shot was given. Sometimes surgery was needed for these skin problems. Talk with the doctor.
• If you are 65 or older, use Bydureon with care. You could have more side effects.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Use Bydureon as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
• If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
• Follow how to use as you have been told by the doctor or read the package insert.
• Do not use if solution changes color.
• Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.
• Do not mix Bydureon in the same syringe with insulin.
• Give this medicine at some other site from where you gave your insulin if you are also getting insulin.
• Wash your hands before and after use.
• Follow the diet and workout plan that your doctor told you about.
• Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
• This medicine needs to be mixed before use. Follow how to mix as you were told by the doctor.
• Use right away after mixing.
• Take the same day each week.
• Move site where you give the shot each time.
• Take with or without food.
• This medicine will look cloudy and milky when ready to use. Do not use if the solution looks clear or has lumps in it. Do not use if powder is stuck to the sides of the container.
• Do not use if the solution is leaking or has particles.
• Each pen or tray is for one use only. Throw away any part of the container not used after the shot is given.
• Before giving the shot, let it come to room temperature. Do not heat Bydureon (exenatide extended-release injection (bydureon) (pens)).

What do I do if I miss a dose?

• If it is 3 or more days to the time of your next dose, take the missed dose as soon as you think about it and go back to your normal day.
• If it is 1 or 2 days to the time of your next dose, skip the missed dose and go back to your normal day.
• Do not take 2 doses at the same time or extra doses.

Dosage Information (comprehensive)

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Hard stools (constipation).
• Feeling tired or weak.
• Itching where the shot is given.
• Upset stomach or throwing up.
• Loose stools (diarrhea).
• Headache.
• Small bump where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side Effects (complete list)

• Store in a refrigerator or at room temperature. If stored at room temperature, throw away any part not used after 28 days.
• Do not freeze.
• Do not use if it has been frozen.
• Protect from light.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine is refilled. If you have any questions about Bydureon, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Bydureon. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Bydureon.

Review Date: December 6, 2017