Apixaban (Oral Route)
Name: Apixaban (Oral Route)
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of apixaban in the elderly.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | B | Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Defibrotide
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abciximab
- Aceclofenac
- Acemetacin
- Acenocoumarol
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amtolmetin Guacil
- Anagrelide
- Anistreplase
- Argatroban
- Aspirin
- Bemiparin
- Bivalirudin
- Bromfenac
- Bufexamac
- Cangrelor
- Carbamazepine
- Celecoxib
- Ceritinib
- Choline Salicylate
- Cilostazol
- Citalopram
- Clarithromycin
- Clonixin
- Clopidogrel
- Cobicistat
- Collagenase, Clostridium histolyticum
- Conivaptan
- Dabigatran Etexilate
- Dalteparin
- Danaparoid
- Desirudin
- Desvenlafaxine
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Diltiazem
- Dipyridamole
- Dipyrone
- Dronedarone
- Drotrecogin Alfa
- Droxicam
- Duloxetine
- Edoxaban
- Eliglustat
- Enoxaparin
- Epoprostenol
- Eptifibatide
- Erythromycin
- Escitalopram
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenofibrate
- Fenofibric Acid
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Fluconazole
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Fosphenytoin
- Heparin
- Ibuprofen
- Idelalisib
- Iloprost
- Indomethacin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lepirudin
- Levomilnacipran
- Lopinavir
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Milnacipran
- Morniflumate
- Nabumetone
- Nadroparin
- Naproxen
- Nefazodone
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nintedanib
- Orlistat
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Paroxetine
- Pentosan Polysulfate Sodium
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Phenytoin
- Piketoprofen
- Piracetam
- Piroxicam
- Pranoprofen
- Prasugrel
- Primidone
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C
- Reteplase, Recombinant
- Rifampin
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Selexipag
- Sertraline
- Sibutramine
- Simeprevir
- St John's Wort
- Streptokinase
- Sulfinpyrazone
- Sulindac
- Telaprevir
- Tenecteplase
- Tenoxicam
- Tiaprofenic Acid
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tipranavir
- Tirofiban
- Tolfenamic Acid
- Tolmetin
- Treprostinil
- Urokinase
- Valdecoxib
- Venlafaxine
- Verapamil
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding, active or
- Liver disease, severe or
- Prosthetic (artificial) heart valve—Should not be used in patients with these conditions.
- Bleeding problems, history of or
- Catheter insertion in the spine or
- Liver disease, mild to moderate or
- Surgery (eg, spine), recent or history of—Use with caution. The risk of bleeding may be increased.
- Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For prevention of deep venous thrombosis (hip replacement surgery):
- Adults—2.5 milligrams (mg) two times a day, for 35 days. The first dose should be taken 12 to 24 hours after surgery.
- Children—Use and dose must be determined by your doctor.
- For prevention deep venous thrombosis (knee replacement surgery):
- Adults—2.5 milligrams (mg) two times a day, for 12 days. The first dose should be taken 12 to 24 hours after surgery.
- Children—Use and dose must be determined by your doctor.
- For prevention of reoccurring deep venous thrombosis and pulmonary embolism:
- Adults—2.5 milligrams (mg) two times a day, after at least 6 months of treatment for deep venous thrombosis or pulmonary embolism.
- Children—Use and dose must be determined by your doctor.
- For prevention of strokes and blood clots in patients with nonvalvular atrial fibrillation:
- Adults—5 milligrams (mg) two times a day.
- Adults with 2 of the following characteristics: 80 years of age and older, body weight of 60 kilograms (kg) or less, or kidney problems—2.5 mg two times a day.
- Children—Use and dose must be determined by your doctor.
- For treatment of deep venous thrombosis and pulmonary embolism:
- Adults—At first, 10 milligrams (mg) two times a day, for the first 7 days. Then, your doctor may give you 5 mg two times a day.
- Children—Use and dose must be determined by your doctor.
- For prevention of deep venous thrombosis (hip replacement surgery):