Fibrin

Aprotinin, calcium chloride, fibrinogen, and thrombin combination is used to help control bleeding during surgery when other procedures to close a wound or incision, such as stitches, bands, and heat cannot be used. It is also used to help skin tissues stick together during skin graft or cosmetic surgery (eg, burn treatment or facelift procedures). This medicine is a fibrin sealant.

Artiss™ and Tisseel™ contain man-made proteins (aprotinin, fibrinogen, and thrombin) that are used to stop bleeding by helping the blood to clot.

This medicine is to be given only by or under the supervision of your doctor.

This product is available in the following dosage forms:

• Solution

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Artiss™ and Tisseel™ in children.

Appropriate studies on the relationship of age to the effects of Artiss™ have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Tisseel™ in the elderly.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.