Anti-inhibitor coagulant complex

Name: Anti-inhibitor coagulant complex

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What other drugs will affect anti-inhibitor coagulant complex?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • coagulation factor VIIa;

  • aminocaproic acid; or

  • tranexamic acid.

This list is not complete. Other drugs may interact with anti-inhibitor coagulant complex, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Introduction

Anti-inhibitor coagulant complex, also known as activated prothrombin complex concentrate (APCC) is a preparation containing precursor and activated forms of blood coagulation factors II, VII, IX, and X derived from pooled human venous plasma.3 7 14 24

Actions

  • Contains precursor and activated forms of factors II, VII, IX, and X; principally activated form of factor VII and non-activated forms of factors II, IX, and X.13 14 24 25 72

  • Exact mechanism of action not established, but appears to be multifactorial, involving simultaneous bypassing action in the common, intrinsic, and extrinsic coagulation pathways.7 9 13 14 16 18 22 25 42 72

  • Efficacy of anti-inhibitor coagulant complex may be related in part to the presence of activated factors (e.g., factor Xa and/or factor VIIa), which leads to more complete factor X activation in conjunction with tissue factor, phospholipid, and ionic calcium, thus allowing the coagulation process to proceed beyond those stages where factor VIII is needed.13 22 24 42

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