Antilirium

Because you will receive physostigmine in a clinical setting, you are not likely to miss a dose.

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

• increased urination or bowel movements;

• stomach cramps;

• severe or worsening nausea or vomiting;

• increased sweating;

• blurred vision; or

• excessive saliva in your mouth.

Common side effects may include:

• nausea, vomiting;

• increased salivation; or

• slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Reversible anticholinesterase agent.a

• Inhibits acetylcholinesterase and prolongs and exaggerates the central and peripheral effects of acetylcholine.149 b

• Produces generalized cholinergic responses including miosis, increased tonus of intestinal musculature, constriction of bronchi, and stimulation of secretion by salivary and sweat glands.b

• At sufficiently high dosage, directly blocks action at autonomic ganglia, causes muscle fasciculation and, ultimately, depolarization block.b

• Some evidence that physostigmine may potentiate cholinergic mechanisms involved in memory storage and may improve short-term memory.b

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

• increased urination or bowel movements;
• stomach cramps;
• severe or worsening nausea or vomiting;
• increased sweating;
• blurred vision; or
• excessive saliva in your mouth.

Common side effects may include:

• nausea, vomiting;
• increased salivation; or
• slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Data not available

Atropine is an antidote for physostigmine. Because of the possibility of hypersensitivity in an occasional patient, atropine sulfate injection should always be at hand when physostigmine is administered.

Administration advice:
-Rapid administration can cause bradycardia, hypersalivation leading to respiratory difficulties, and convulsions.

Storage requirements:
-Store at controlled room temperature.
-Protect from light.