Amlodipine-perindopril Oral Tablet

Perindopril/amlodipine is a combination of two drugs in a single form that work in different ways to treat hypertension (high blood pressure). It can be used alone or together with other blood pressure medications.

The standard starting dose is 3.5 mg perindopril/2.5 mg amlodipine once daily.The maximum dose is 14 mg perindopril/10 mg amlodipine once daily. Your doctor will decide a dose that’s right for you.

Common side effects include swelling of your feet, ankles, and hands, persistent cough, headache, and dizziness.

Serious side effects include life-threatening allergic reactions, low blood pressure, high potassium levels in your blood, and kidney problems.

This drug can harm or be fatal to an unborn baby. You shouldn’t take perindopril/amlodipine if you’re pregnant or plan to become pregnant.

IMPORTANT INFORMATION

• FDA warning See Details

• Allergic reaction See Details

• Low blood pressure (hypotension) See Details

What is perindopril/amlodipine?

This drug is a prescription drug. It’s available as an oral tablet. It’s only available as a brand-name drug.

This drug is a combination drug. It contains two drugs: perindopril and amlodipine. It is important to know about all the drugs in the combination because each drug may affect you in a different way.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

This drug is used to treat high blood pressure. It’s given when your doctor thinks you’ll need more than one drug to lower your high blood pressure. It is also given after you have used one drug and it wasn’t enough to lower your high blood pressure.

How it works

This drug is a combination of two drugs in a single form. Perindopril belongs to a class of drugs called angiotensin-converting enzyme inhibitors. Amlodipine belongs to a class of drugs called calcium channel blockers.

More Details

Most Common Side Effects

The more common side effects that occur with perindopril/amlodipine include:

• swelling of your feet, ankles, and hands

• persistent cough

• headache

• dizziness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Low white blood cell counts. Symptoms can include:

  • flu-like symptoms
  • fever
  • chills

• Heart failure. Symptoms can include:

  • swelling of your ankles and legs
  • weight gain
  • shortness of breath

• Liver damage. Symptoms can include:

  • yellowing of your skin and whites of your eyes
  • extreme tiredness
  • severe nausea
  • loss of appetite
  • dark-colored urine

• Serious allergic reactions. Symptoms can include:

  • swelling of your face, lips, tongue, throat, arms, hands, legs, or feet
  • trouble swallowing
  • trouble breathing
  • stomach pain with or without nausea or vomiting

• Low blood pressure (hypotension). Your risk may be higher if you take water pills (diuretics), eat a low salt diet, are on dialysis, have heart problems, vomiting, or diarrhea. Symptoms can include:

  • dizziness
  • feeling faint

• Fluid and electrolyte imbalance. Symptoms can include:

  • dry mouth
  • feeling thirsty
  • weakness
  • tiredness
  • drowsiness
  • restlessness
  • confusion
  • seizures
  • muscle pains or cramps
  • low blood pressure (hypotension)
  • a decrease in the amount of urine you produce (oliguria)
  • a fast heart rate (tachycardia)
  • nausea and vomiting

• Kidney problems. Symptoms can include:

  • swelling in your feet, ankles, or hands
  • unexplained weight gain

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Perindopril/amlodipine can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

You shouldn’t eat potassium-containing salt substitutes. You should avoid eating excessive amounts of potassium-rich foods. Examples of potassium-rich foods include:

• acorn and butternut squash
• baked potato with skin
• broccoli, zucchini, and Brussels sprouts
• spinach
• collard greens
• lentils, kidney beans, and white navy beans
• split peas
• raisins
• banana
• watermelon
• orange juice
• yogurt

Medications that might interact with this drug

Potassium supplements

These drugs may increase your blood potassium levels when taken with perindopril/amlodipine. These drugs include:

• potassium chloride
• potassium gluconate
• potassium bicarbonate
• potassium bicarbonate and citric acid

Water pills (diuretics)

These drugs may increase your risk for low blood pressure when taken with perindopril/amlodipine. These drugs include:

• bendroflumethiazide
• chlorothiazide
• chlorthalidone
• hydrochlorothiazide
• indapamide
• methyclothiazide
• metolazone
• bumetanide
• ethacrynic acid
• furosemide

Potassium-sparing diuretics

Potassium-sparing diuretics may increase your blood potassium levels when taken with perindopril/amlodipine. These drugs include:

• spironolactone
• amiloride
• triamterene
• torsemide

Bipolar disorder drugs

Taking perindopril/amlodipine with lithium can increase the levels of lithium in your body. This may cause more side effects.

High cholesterol drugs

You shouldn’t take more than 20 mg of high cholesterol drug simvastatin each day while you’re taking perindopril/amlodipine. Perindopril/amlodipine can increase the levels of simvastatin in your body. This may cause more side effects.

Drugs to prevent organ transplant rejection

Perindopril/amlodipine can increase the levels of the organ transplant drug cyclosporine in your body. This may cause more side effects.

Antifungal drugs

These drugs can increase the levels of perindopril/amlodipine in your blood. This raises your risk of side effects. These drugs include:

• itraconazole
• ketoconazole
• posaconazole
• voriconazole

HIV and hepatitis C virus infection drugs

These drugs can increase the levels of perindopril/amlodipine in your blood. This raises your risk of side effects. These drugs include:

• ritonavir
• atazanavir
• fosamprenavir
• indinavir
• nelfinavir
• saquinavir
• tipranavir

Heart drugs

The heart drug diltiazem can increase the levels of perindopril/amlodipine in your blood. This raises your risk of side effects.

High blood pressure or heart failure drugs

These drugs may increase your risk for low blood pressure, high potassium levels in your blood, and kidney problems when taken with perindopril/amlodipine. These drugs include:

• angiotensin receptor blockers, such as:
  • azilsartan
  • candesartan
  • eprosartan
  • irbesartan
  • losartan
  • olmesartan
  • telmisartan
  • talsartan

• angiotensin-converting enzyme inhibitors, such as:
  • benazepril
  • captopril
  • enalapril
  • fosinopril
  • lisinopril
  • moexipril
  • perindopril
  • quinapril
  • ramipril
  • trandolapril

• direct renin inhibitor:
  • aliskiren

Pain and osteoarthritis drugs

These drugs may decrease the effectiveness of perindopril/amlodipine. This means that it won’t work as well to lower your blood pressure. These drugs may also increase your risk of kidney problems. These drugs include:

• celecoxib
• diclofenac
• etodolac
• fenoprofen
• flurbiprofen
• ibuprofen
• indomethacin
• ketoprofen
• ketorolac
• meclofenamate
• mefenamic acid
• meloxicam
• nabumetone
• naproxen
• oxaprozin
• piroxicam
• sulindac
• tolmetin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Drug warnings

People with heart problems

If you have heart problems, such as narrowing of your arteries, you may have a higher risk for worsening chest pain or a heart attack while taking this drug. Your risk may be higher soon after starting or during dose increases of this drug. If you have more chest pain, call your doctor right away or go to the emergency room.

People with liver problems

You shouldn’t take this drug if you have liver problems. This drug is processed in your liver. If you have liver problems, your liver may not be able to process this drug like it should. This can cause the drug to build up in your body and increase your risk of side effects such as very low blood pressure and dizziness.

People with kidney problems

This drug can worsen your kidney function or even cause new kidney problems. Your doctor may need to reduce your dose, or you may need to stop using this drug. Your doctor may do blood tests to see how the drug is affecting your kidneys. You may also be more sensitive to this drug if you have a history of kidney problems.

If you have kidney problems, you are also at increased risk of high blood potassium. Potassium is a mineral that helps your nerves, muscles, and organs work normally. Very high levels of potassium can cause heart rhythm problems that can be life-threatening.

People with diabetes

If you have diabetes, do not take this drug if you take the drug aliskiren. Taking these drugs together has been shown to increase the risk of stroke, kidney problems, high potassium, and low blood pressure.

People with high blood potassium levels

This drug can increase potassium levels in your blood. You shouldn’t take this drug if you already have high potassium levels (hyperkalemia). Your doctor will check your blood potassium levels before giving you this medication.

People with dehydration

This drug may cause low blood pressure in people who are dehydrated. You may get dehydrated from being sick or having vomiting or diarrhea.

Pregnant women

This drug is a category D pregnancy drug. That means two things:

1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

This drug can harm or be fatal to your unborn baby. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. If you become pregnant while taking this drug, tell your doctor right away. They may switch you to a different medication.

Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause serious effects in a breast-feeding child.

You and your doctor may need to decide if you’ll breast-feed or take this drug.

For children

This medicine hasn’t been studied in children and shouldn’t be used in people younger than 18 years.

Allergies

This drug can cause serious allergic reactions. Symptoms include:

• swelling of your face, lips, tongue, throat, arms, hands, legs, or feet
• trouble swallowing
• trouble breathing
• stomach (abdomen) pain with or without nausea or vomiting

People who are black may have a higher risk of an allergic reaction.

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Prestalia

Form: Oral tablet Strengths:

• 3.5 mg perindopril/2.5 mg amlodipine
• 7 mg perindopril/5 mg amlodipine
• 14 mg perindopril/10 mg amlodipine

Adult dosage (ages 18–64 years):

• Starting dose: 3.5 mg perindopril/2.5 mg amlodipine, taken by mouth, once per day
• Dose changes: If your blood pressure is still high after 1–2 weeks, your doctor may increase your dose.
• Maximum dose: 14 mg perindopril/10 mg amlodipine, taken once per day

Child dosage (ages 0–17 years):

This drug hasn’t been studied in children and shouldn’t be used in people younger than 18 years.

Senior dosage (ages 65 years and older):

If you need to take this drug at a dosage higher than 7 mg perindopril/5 mg amlodipine, your doctor will likely monitor your blood pressure for up to two weeks after every dose increase above this amount.

Special considerations

People with kidney disease: Your doctor will decide your dosage based on how well your kidneys function. If you have severe kidney disease, your doctor may not prescribe this drug for you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. Important considerations for taking this drug

This drug may be taken with or without food

You can cut and crush the tablet

Store this drug carefully

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Prescription is refillable

Travel

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Clinical monitoring

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Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.

Insurance

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Are there any alternatives?