Aminocaproic acid

Take aminocaproic acid exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Aminocaproic Acid dose your doctor recommends will be based on the following (use any or all that apply):

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Aminocaproic Acid is available in the following doses:

• Aminocaproic Acid 1.25 G/5 Ml Oral Syrup
• Aminocaproic Acid 1000 Mg Oral Tablet
• Aminocaproic Acid 250 Mg/ml Intravenous Solution
• Aminocaproic Acid 500 Mg Oral Tablet
• Aminocaproic Acid Compounding Powder

Dosage Forms & Strengths

injectable solution

• 250mg/mL

syrup

• 1.25g/5mL

tablet

• 500mg
• 1,000mg

Fibrinolytic Bleeding

Initial: 4-5 g IV/PO during 1st hr, THEN 1-1.25 g PO q1hr, OR

Continuous IV infusion at 1 g/hr 

Continue for 8 hr or until bleeding controlled, not to exceed 30 g/day

Decrease dose in cardiac, renal, or hepatic disease

Control of Bleeding with Severe Thrombocytopenia (Off-label)

Initial: 100 mg/kg IV over 30-60 min; not to exceed 5 g

Maintenance: 1-4 g PO/IV q4-8hr for 1 g/hr; not to exceed 24 g/24hr

Hyphema (Orphan)

Topical gel (Caprogel) for treatment of traumatic hyphema of the eye

Administration: Topical

Orphan indication sponsor

• Eastern Virginia Medical School Department of Ophthalmology; 880 Kempsville Road, Suite 2500; Norfolk, VA 23502-3990

Other Indications & Uses

Bleeding due to systemic hyperfibrinolysis

Off-label: prevent recurrence of subarachnoid hemorrhage; prevent hereditary angioneurotic edema attacks; reduce post-op bleeding

Dosage Forms & Strengths

injectable solution

• 250mg/mL

syrup

• 1.25g/5mL

tablet

• 500mg

Prevention of Perioperative Bleeding Associated with Cardiac Surgery (Off-label)

100 mg/kg IV over 20-30 min after induction prior to incision

100 mg/kg IV over 20-30 min during cardiopulmonary bypass

100 mg/kg IV after heparin reversal

Aminocaproic acid is a man-made form of a protein that occurs naturally in the body and helps the blood to clot.

Aminocaproic acid is used to treat bleeding episodes in people with certain medical conditions such as aplastic anemia (lack of blood cells and platelets), cirrhosis of the liver, placenta abruptio (early separation of the placenta in pregnancy), urinary bleeding, and certain types of cancer.

Aminocaproic acid is also used to prevent bleeding after heart surgery or placement of a shunt near the liver to control high blood pressure.

Aminocaproic acid may also be used for purposes not listed in this medication guide.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using aminocaproic acid and call your doctor at once if you have:

• unexplained muscle pain or weakness (especially if you also have fever, unusual tiredness, or dark colored urine);

• sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising, unusual bleeding;

• numbness, tingling, or cold feeling in your arms or legs;

• slow heart rate, trouble breathing, feeling like you might pass out;

• kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or

• signs of a blood clot--sudden numbness or weakness, tingling or cold feeling in an arm or leg, trouble breathing, sudden cough or chest pain, or swelling, warmth, or redness in your arms or legs.

Common side effects may include:

• muscle weakness;

• headache;

• nausea, vomiting, stomach pain, diarrhea;

• (in men) decreased amount of semen when having an orgasm;

• stuffy nose, watery eyes;

• vision problems, ringing in your ears; or

• itching, rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

(a mee noe ka PROE ik AS id)

• EACA
• Epsilon Aminocaproic Acid

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Intravenous:

Generic: 250 mg/mL (20 mL)

Solution, Oral:

Amicar: 25% (236.5 mL) [contains edetate disodium, methylparaben, propylparaben, saccharin sodium; raspberry flavor]

Syrup, Oral:

Amicar: 25% (473 mL [DSC])

Generic: 25% (237 mL [DSC], 473 mL [DSC])

Tablet, Oral:

Amicar: 500 mg [DSC]

Amicar: 500 mg [scored]

Amicar: 1000 mg [DSC]

Amicar: 1000 mg [scored]

Generic: 500 mg [DSC], 1000 mg [DSC]

• Amicar

Prevention of perioperative bleeding associated with cardiac surgery (off-label use): IV: 100 mg/kg given over 20-30 minutes after induction and prior to incision, 100 mg/kg during cardiopulmonary bypass, and 100 mg/kg after heparin reversal over 3 hours (Chauhan, 2004)

Prevention of bleeding associated with extracorporeal membrane oxygenation (ECMO) (off-label use): IV: 100 mg/kg prior to or immediately after cannulation, followed by 25-30 mg/kg/hour for up to 72 hours (Downard, 2003; Horwitz, 1998; Wilson, 1993)

Prevention of perioperative bleeding associated with spinal surgery (eg, idiopathic scoliosis) (off-label use): Children and Adolescents: IV: 100 mg/kg given over 15-20 minutes after induction, followed by 10 mg/kg/hour for the remainder of the surgery; discontinue at time of wound closure (Florentino-Pineda, 2001; Florentino-Pineda, 2004)

Traumatic hyphema (off-label use): Oral: Refer to adult dosing.

Animal reproduction studies have not been conducted.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.