Aminolevulinic Acid Hydrochloride

Photosensitizer; hydrochloride salt of 5-aminolevulinic acid, an endogenous precursor of protoporphyrin IX.1 2

No formal drug interaction studies performed.a No drug-specific interactions noted during controlled clinical trials.a

Other Known Photosensitizing Agents

Potential pharmacologic interaction (increased photosensitivity reaction) with other known photosensitizing agents (e.g., griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides, tetracyclines).a

• Aminolevulinic acid hydrochloride topical solution is not meant for application by patient.a Only qualified health professionals should apply drug.a

• Importance of advising patient to keep lesions dry and out of bright light following application of the topical solution.a

• Importance of informing patient of possible transient stinging and/or burning at treated lesion sites if exposed to bright light following topical solution application;a patient should reduce exposure to light if this occurs.a Importance of patient wearing light-protective clothing, such as a wide-brimmed hat or similar head covering of light-opaque material, before going into sunlight following topical solution application.a Importance of informing patient that sunscreens will not protect against photosensitivity reactions caused by visible light.a Importance of patient limiting exposure to bright indoor light following topical solution application.a

• Importance of informing patient that transient tingling, stinging, prickling, and/or burning may occur at target lesion sites during period of blue light photoactivation.a

• Importance of patient informing clinicians of existing or contemplated therapy, including prescription and OTC drugs.a

• Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.a

• Importance of informing patients of other important precautionary information. (See Cautions.)

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.