Amiodarone Intravenous

In the U.S.

• Cordarone IV

Available Dosage Forms:

• Solution

Therapeutic Class: Antiarrhythmic, Group III

Chemical Class: Benzofuran

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amiodarone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to amiodarone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amiodarone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amiodarone injection in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving amiodarone injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving amiodarone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using amiodarone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amifampridine
• Amisulpride
• Bepridil
• Cisapride
• Colchicine
• Dronedarone
• Fingolimod
• Fluconazole
• Grepafloxacin
• Indinavir
• Ketoconazole
• Levomethadyl
• Mesoridazine
• Nelfinavir
• Pimozide
• Piperaquine
• Posaconazole
• Ritonavir
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tipranavir
• Vernakalant
• Ziprasidone

Using amiodarone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone
• Acecainide
• Afatinib
• Agalsidase Alfa
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amlodipine
• Amprenavir
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Artemether
• Asenapine
• Astemizole
• Atazanavir
• Azimilide
• Azithromycin
• Bedaquiline
• Betrixaban
• Bicalutamide
• Boceprevir
• Bretylium
• Buserelin
• Ceritinib
• Chloral Hydrate
• Chloroquine
• Chlorpromazine
• Cilostazol
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clozapine
• Cobicistat
• Conivaptan
• Crizotinib
• Cyclobenzaprine
• Dabigatran Etexilate
• Dabrafenib
• Daclatasvir
• Dasabuvir
• Dasatinib
• Degarelix
• Delamanid
• Delavirdine
• Desipramine
• Deslorelin
• Deutetrabenazine
• Digoxin
• Diltiazem
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Droperidol
• Ebastine
• Efavirenz
• Eliglustat
• Encainide
• Enflurane
• Eribulin
• Erythromycin
• Escitalopram
• Etravirine
• Famotidine
• Felbamate
• Felodipine
• Fentanyl
• Flecainide
• Flunarizine
• Fluoxetine
• Fluvoxamine
• Formoterol
• Fosamprenavir
• Foscarnet
• Fosphenytoin
• Galantamine
• Gallopamil
• Gatifloxacin
• Gemifloxacin
• Ginkgo Biloba
• Goldenseal
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Halothane
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Idelalisib
• Iloperidone
• Imipramine
• Indecainide
• Iohexol
• Isoflurane
• Isoniazid
• Isradipine
• Itraconazole
• Ivabradine
• Lacidipine
• Lapatinib
• Ledipasvir
• Lercanidipine
• Leuprolide
• Levofloxacin
• Lidocaine
• Lidoflazine
• Lopinavir
• Loratadine
• Lovastatin
• Lumefantrine
• Manidipine
• Mefloquine
• Methadone
• Methotrimeprazine
• Metronidazole
• Mexiletine
• Mibefradil
• Miconazole
• Mifepristone
• Mizolastine
• Moricizine
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nefazodone
• Nicardipine
• Nifedipine
• Nilotinib
• Nilvadipine
• Nisoldipine
• Nitrendipine
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ombitasvir
• Ondansetron
• Ospemifene
• Oxycodone
• Paliperidone
• Panobinostat
• Papaverine
• Paritaprevir
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perhexiline
• Perphenazine
• Pimavanserin
• Pipamperone
• Pitolisant
• Pixantrone
• Pranidipine
• Prilocaine
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranitidine
• Ranolazine
• Regorafenib
• Ribociclib
• Rifampin
• Risperidone
• Salmeterol
• Sematilide
• Sertindole
• Sevoflurane
• Simeprevir
• Simvastatin
• Sirolimus
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Sofosbuvir
• Solifenacin
• Sorafenib
• Sotalol
• Spiramycin
• St John's Wort
• Sulfamethoxazole
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tedisamil
• Telaprevir
• Telavancin
• Telithromycin
• Tetrabenazine
• Ticagrelor
• Tizanidine
• Tocainide
• Tolterodine
• Topotecan
• Toremifene
• Trazodone
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vasopressin
• Vemurafenib
• Venetoclax
• Venlafaxine
• Verapamil
• Vilanterol
• Vincristine
• Vincristine Sulfate Liposome
• Vinflunine
• Voriconazole
• Vorinostat
• Warfarin
• Zileuton
• Zolmitriptan
• Zotepine
• Zuclopenthixol

Using amiodarone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abarelix
• Acebutolol
• Acenocoumarol
• Alprenolol
• Atenolol
• Atorvastatin
• Betaxolol
• Bevantolol
• Bisoprolol
• Bucindolol
• Carteolol
• Carvedilol
• Celiprolol
• Cholestyramine
• Clonazepam
• Cyclosporine
• Dicumarol
• Digitoxin
• Dilevalol
• Esmolol
• Labetalol
• Levobunolol
• Mepindolol
• Methotrexate
• Metipranolol
• Metoprolol
• Nadolol
• Nebivolol
• Nevirapine
• Oxprenolol
• Penbutolol
• Phenytoin
• Pindolol
• Propranolol
• Rifapentine
• Rosuvastatin
• Talinolol
• Tertatolol
• Theophylline
• Timolol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of amiodarone. Make sure you tell your doctor if you have any other medical problems, especially:

• AV block (type of abnormal heart rhythm), with no pacemaker or
• Bradycardia (slow heartbeat) or
• Cardiogenic shock or
• Sick sinus syndrome (type of abnormal heart rhythm), with no pacemaker—Should not be used in patients with these conditions.

• Eye or vision problems or
• Heart rhythm problems (e.g., QT prolongation) or
• Hypokalemia (low potassium in the blood) or
• Hypomagnesemia (low magnesium in the blood) or
• Hypotension (low blood pressure) or
• Lung disease or other breathing problems or
• Thyroid problems—Use with caution. May make these conditions worse.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• sweating
• unusual tiredness or weakness

• Black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• blood in the urine or stools
• chest pain or discomfort
• chills
• cold, clammy skin
• cough
• decreased urine output
• diarrhea
• difficulty with breathing
• dilated neck veins
• dizziness
• extreme fatigue
• fainting
• fast, pounding, or irregular heartbeat or pulse
• fast, weak pulse
• fever
• irregular heartbeat recurrent
• itching
• joint or muscle pain
• lightheadedness, dizziness, or fainting
• no blood pressure or pulse
• pinpoint red spots on the skin
• red, irritated eyes
• red skin lesions, often with a purple center
• shortness of breath
• slow or irregular heartbeat
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• stopping of the heart
• swelling of the face, fingers, feet, or lower legs
• tightness in the chest
• troubled breathing
• unconsciousness
• unusual bleeding or bruising
• weight gain
• wheezing

• Abdominal or stomach pain
• agitation
• back, leg, or stomach pains
• bleeding gums
• bloating
• blurred or double vision
• clay-colored stools
• coma
• confusion about identity, place, and time
• cough or hoarseness
• coughing or spitting up blood
• cracks in the skin
• dark-colored urine
• decreased frequency or amount of urine
• decreased urine output
• depression
• difficulty swallowing
• eye pain
• fever with or without chills
• general body swelling
• general feeling of tiredness or weakness
• headache
• high fever
• hives
• holding false beliefs that cannot be changed by fact
• hostility
• increased blood pressure
• increased thirst
• indigestion
• inflamed tissue from infection
• irritability
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• lethargy
• light-colored stools
• loss of appetite
• loss of heat from the body
• lower back or side pain
• muscle cramps or spasms
• muscle pain or stiffness
• muscle twitching
• muscular pain, tenderness, wasting, or weakness
• noisy breathing
• nosebleeds
• painful or difficult urination
• pains in the stomach, side, or abdomen, possibly radiating to the back
• pale skin
• persistent non-healing sore
• pink growth
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• rash
• red, swollen skin
• reddish patch or irritated area
• redness, soreness, or itching skin
• scaly skin
• seeing, hearing, or feeling things that are not there
• seizures
• severe headache
• shiny bump
• sores, welting, or blisters
• stupor
• swollen or painful glands
• unexplained bleeding or bruising
• unpleasant breath odor
• unusual excitement, nervousness, or restlessness
• upper right abdominal pain
• vomiting
• vomiting of blood
• weakness
• white, yellow, or waxy scar-like area
• yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Consult your pharmacist.

Consult your pharmacist.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Missed Dose

Consult your pharmacist.

Storage

Consult your pharmacist.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.