Zofran Oral, Oromucosal

Name: Zofran Oral, Oromucosal

Zofran Oral, Oromucosal side effects
Zofran Oral, Oromucosal tablet
Zofran Oral, Oromucosal drug
Zofran Oral, Oromucosal effects of
Zofran Oral, Oromucosal the effects of
Zofran Oral, Oromucosal 8 mg
Zofran Oral, Oromucosal dosage
Zofran Oral, Oromucosal dosage forms
Zofran Oral, Oromucosal average dose
Zofran Oral, Oromucosal missed dose

Uses For Zofran

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Before Using Zofran

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ondansetron in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine
Amisulpride
Apomorphine
Bepridil
Cisapride
Dronedarone
Fluconazole
Ketoconazole
Mesoridazine
Nelfinavir
Pimozide
Piperaquine
Posaconazole
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide
Alfentanil
Alfuzosin
Amiodarone
Amitriptyline
Amoxapine
Amphetamine
Anagrelide
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Atazanavir
Azimilide
Azithromycin
Bedaquiline
Benzphetamine
Bretylium
Buprenorphine
Bupropion
Buserelin
Butorphanol
Ceritinib
Chloroquine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Codeine
Conivaptan
Crizotinib
Cyclobenzaprine
Dabrafenib
Darunavir
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Dextroamphetamine
Dihydrocodeine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Ebastine
Efavirenz
Enflurane
Eribulin
Erythromycin
Escitalopram
Famotidine
Felbamate
Fentanyl
Fingolimod
Flecainide
Fluoxetine
Foscarnet
Fosphenytoin
Galantamine
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydrocodone
Hydromorphone
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Idelalisib
Iloperidone
Imipramine
Isoflurane
Isradipine
Itraconazole
Ivabradine
Lapatinib
Leuprolide
Levofloxacin
Levorphanol
Lisdexamfetamine
Lopinavir
Lumefantrine
Mefloquine
Meperidine
Methadone
Methamphetamine
Methylene Blue
Metronidazole
Mifepristone
Mirtazapine
Mizolastine
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nafarelin
Nalbuphine
Netupitant
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Olanzapine
Oxycodone
Oxymorphone
Paliperidone
Panobinostat
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Pentazocine
Perphenazine
Pimavanserin
Pitolisant
Pixantrone
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Remifentanil
Ribociclib
Rilpivirine
Risperidone
Ritonavir
Salmeterol
Sematilide
Sertindole
Sevoflurane
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Sufentanil
Sulpiride
Sunitinib
Tacrolimus
Tamoxifen
Tapentadol
Tedisamil
Telavancin
Telithromycin
Tetrabenazine
Tizanidine
Tolterodine
Toremifene
Tramadol
Trazodone
Trifluoperazine
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vinflunine
Voriconazole
Vorinostat
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cyclophosphamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Tobacco

Proper Use of ondansetron

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry.
Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine.
Fold the pouch along the dotted line to expose the tear notch.
While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets):
- For prevention of moderate nausea and vomiting after treatment with cancer medicines:
  - Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days.
  - Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days.
  - Children younger than 4 years of age—Use and dose must be determined by your doctor.
- For prevention of more severe nausea and vomiting after treatment with cancer medicines:
  - Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment.
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For prevention of nausea and vomiting after radiation treatment:
  - Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours.
  - Children—Use and dose must be determined by your doctor.
- For prevention of nausea and vomiting after surgery:
  - Adults—16 milligrams (mg) one hour before anesthesia is given.
  - Children—Use and dose must be determined by your doctor.
For oral dosage form (soluble film):
- For prevention of moderate nausea and vomiting after treatment with cancer medicines:
  - Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days.
  - Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days.
  - Children younger than 4 years of age—Use and dose must be determined by your doctor.
- For prevention of more severe nausea and vomiting after treatment with cancer medicines:
  - Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film.
  - Children—Use and dose must be determined by your doctor.
- For prevention of nausea and vomiting after radiation treatment:
  - Adults—One 8-milligram (mg) film three times a day.
  - Children—Use and dose must be determined by your doctor.
- For prevention of nausea and vomiting after surgery:
  - Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Precautions While Using Zofran

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

Do not use this medicine if you are receiving apomorphine (Apokyn®). Using these medicines together may increase risk for more serious problems.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Zofran Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Confusion
dizziness
fast heartbeat
fever
headache
shortness of breath
weakness

Less common

Decrease in the frequency of urination
decrease in the urine volume
difficulty with passing urine (dribbling)
painful urination

Rare

Arm, back, or jaw pain
chest pain or discomfort
chest tightness or heaviness
convulsions
cough
decreased urine
difficulty with breathing
difficulty with swallowing
dry mouth
fast, pounding, or irregular heartbeat or pulse
increased thirst
loss of appetite
loss of bladder control
loss of consciousness
mood changes
muscle pain or cramps
nausea or vomiting
noisy breathing
numbness or tingling in the hands, feet, or lips
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
skin rash, hives, or itching
sweating
tightness in the chest
total body jerking
unusual tiredness or weakness
wheezing

Incidence not known

Blurred vision
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fixed position of the eye
heart stops
hoarseness
inability to move the eyes
increased blinking or spasms of the eyelid
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
no breathing
no pulse or blood pressure
noisy breathing
pounding heartbeat
slow or irregular breathing
sticking out of the tongue
sweating
trouble with speaking
unconscious
uncontrolled twisting movements of the neck, trunk, arms, or legs
unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: