XaQuil XR

Name: XaQuil XR

What should I discuss with my health care provider before taking XaQuil XR (l-methylfolate)?

You should not use l-methylfolate if you are allergic to it.

To make sure l-methylfolate is safe for you, tell your doctor if you have:

  • seizures or epilepsy;

  • a history of vitamin B12 deficiency or pernicious anemia; or

  • a history of bipolar disorder (manic depression).

Tell your doctor if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing.

How should I take XaQuil XR (l-methylfolate)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Use only the strength of l-methylfolate that your doctor has prescribed. Do not switch brands without your doctor's advice.

You may take l-methylfolate with or without food. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Do not share this medication with another person, even if they have the same symptoms you have.

L-methylfolate is only part of a complete program of treatment that may also include other medications, and psychological counseling when used in people with depression or schizophrenia. Follow your medication and counseling routines very closely.

Store at cool room temperature away from moisture, heat, and light.

What happens if I overdose?

An overdose of l-methylfolate is not likely to cause life-threatening symptoms.

What other drugs will affect XaQuil XR (l-methylfolate)?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • capecitabine;

  • fluoxetine (Prozac);

  • isotretinoin;

  • methotrexate;

  • methylprednisolone;

  • pancrelipase;

  • pyrimethamine;

  • triamterene;

  • trimethoprim;

  • warfarin (Coumadin, Jantoven);

  • birth control pills;

  • oral diabetes medicine that contains metformin (Glucophage, Avandamet, Metaglip, and others);

  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or

  • seizure medicine--carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, valproic acid.

This list is not complete. Other drugs may interact with l-methylfolate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

For the Consumer

Applies to l-methylfolate: oral capsule, oral tablet

For Healthcare Professionals

Applies to l-methylfolate: oral capsule, oral tablet, oral tablet extended release


Hypersensitivity side effects including allergic reactions have been reported.[Ref]

Some side effects of XaQuil XR may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.