Wycillin

Penicillin G potassium is a prescription medication used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with penicillin G potassium. See the “Drug Precautions” section.

Common side effects include:

• an allergic reaction, with symptoms of itching, redness and warmth of skin, and swelling that may occur
• itching of the skin
• skin rash

This is not a complete list of penicillin G potassium side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Serious side effects have been reported with penicillin G potassium including:

• hypersensitivity (severe allergic reaction). Signs of a hypersensitivity reaction, which include the following:
  • chest pain
  • swelling of the face, eyes, lips, tongue, arms, or legs
  • difficulty breathing or swallowing
  • fainting
  • rash
  • new or increasing irregularities in your heart rate
• superinfection. penicillin G potassium should not be used for extended periods. Prolonged use can lead to the growth of dangerous organisms that are resistant or unresponsive to this medication. Take penicillin G potassium for the duration prescribed by your doctor.

Do not take penicillin G potassium if you are allergic to any of its ingredients.

Penicillin G potassium is usually administered by a healthcare provider in a medical setting making it unlikely for an overdose to occur. However, if overdose is suspected, seek emergency medical attention.

Procaine penicillin is an antibiotic that fights bacteria in your body.

Procaine penicillin is used to treat many different types of infections caused by bacteria, including syphilis (a sexually transmitted disease).

Do not use this medication for any other infection that has not been checked by your doctor.

Procaine penicillin may also be used for other purposes not listed in this medication guide.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include mood changes, agitation, confusion, and seizure (convulsions).

Applies to procaine penicillin: intramuscular suspension

Get emergency medical help if you have any of these signs of an allergic reaction while taking procaine penicillin (the active ingredient contained in Wycillin) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• diarrhea that is watery or bloody;

• peeling skin , severe pain, or changes in skin color where the medicine was injected;

• dizziness, joint or muscle pain;

• fast or pounding heartbeats;

• numbness, tingling, pain, swelling, or redness in your arms or legs;

• confusion, agitation, depression, unusual thoughts or behavior;

• chest pain, problems with vision or speech;

• feeling like you might pass out;

• fever, chills, dizziness, muscle pain, rapid breathing or heart rate;

• uncontrolled muscle movements, problems with balance or walking;

• pale skin, easy bruising or bleeding, unusual weakness;

• sore throat, flu symptoms;

• urinating less than usual or not at all;

• rash or itching with swollen glands, joint pain, or general ill feeling; or

• slow heart rate, weak pulse, fainting, slow breathing.

Less serious side effects of procaine penicillin may include:

• pain where the injection was given;

• vaginal itching or discharge;

• white patches in your mouth or throat;

• nausea, vomiting;

• blurred vision, ringing in your ears;

• headache, dizziness; or

• mild skin rash,

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Applies to procaine penicillin: intramuscular suspension

Hypersensitivity

Hypersensitivity side effects associated with penicillin have included skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, and serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration). Anaphylaxis (severe and often fatal) and Jarisch-Herxheimer reaction (as with other treatments for syphilis) have been reported. Procaine toxicity manifestations and hypersensitivity reactions have been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects associated with penicillin G have included pseudomembranous colitis.[Ref]

The onset of pseudomembranous colitis symptoms may occur during or after treatment.[Ref]

Psychiatric

Psychiatric side effects have included a syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) following procaine penicillin (the active ingredient contained in Wycillin) use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.[Ref]

Renal

Renal side effects associated with parenteral penicillin G have included nephropathy.[Ref]

Hematologic

Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia.[Ref]

Nervous system

Nervous system side effects associated with parenteral penicillin G have included neuropathy.[Ref]

Some side effects of Wycillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.