Vazculep
Name: Vazculep
- Vazculep uses
- Vazculep mg
- Vazculep injection
- Vazculep used to treat
- Vazculep is used to treat
- Vazculep drug
- Vazculep 10 mg
Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 10mg/mL
Mild to Moderate Hypotension
Initial: 2-5 mg IM or SC; not to exceed 5 mg
Maintenance: 1-10 mg
Severe Hypotension/Shock
100-180 mcg increments IV bolus, THEN
40-60 mcg/min continuous IV infusion
Dosage Forms & Strengths
injectable solution
- 10mg/mL
Hypotension
5-20 mcg/kg IV bolus q10-15min PRN, OR
0.1-0.5 mcg/kg/min IV continuous infusion
Warnings
Black Box Warnings
Physicians should completely familiarize themselves with complete contents of package insert prior to prescribing phenylephrine hydrochloride injection
Contraindications
Hypersensitivity to phenylephrine or sulfites
Severe hypertension
Ventricular tachycardia
Closed-angle glaucoma
Cautions
Cerebrovascular insufficiency
Cardiovascular disease
Hypertension
Diabetes mellitus
Thyroid disease
Prostatic hypertrophy
Geriatric patients
Uses For Vazculep
Phenylephrine injection is used to treat hypotension (low blood pressure) that may occur during surgery.
This medicine is to be given only by or under the direct supervision of your doctor.
Proper Use of Vazculep
A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.
Drug Interactions
Interactions that Augment Pressor Effect
The increasing blood pressure effect of Vazculep is increased in patients receiving:
- Monoamine oxidase inhibitors (MAOI)
- Oxytocin and oxytocic drugs
- Tricyclic antidepressants
- Angiotensin, aldosterone
- Atropine
- Steroids, such as hydrocortisone
- Norepinephrine transporter inhibitors, such as atomoxetine
- Ergot alkaloids, such as methylergonovine maleate
Interactions that Antagonize the Pressor Effect
The increasing blood pressure effect of Vazculep is decreased in patients receiving:
- α-adrenergic antagonists
- Phosphodiesterase Type 5 inhibitors
- Mixed α- and β-receptor antagonists
- Calcium channel blockers, such as nifedipine
- Benzodiazepines
- ACE inhibitors
- Centrally acting sympatholytic agents, such as reserpine, guanfacine
How Supplied/Storage and Handling
Vazculep (phenylephrine hydrochloride) Injection, 10 mg/mL, is supplied as follows:
| NDC No. | Strength | How Supplied |
| 76014-004-25 | 10 mg/mL | 1 mL vial; for single use (supplied in packages of 25) |
| 76014-004-10 | 10 mg/mL | 5 mL vial; Pharmacy Bulk Package (supplied in packages of 10) |
| 76014-004-33 | 10 mg/mL | 10 mL vial; Pharmacy Bulk Package (supplied as a single unit) |
Vial stoppers are not manufactured with natural rubber latex. Store Vazculep (phenylephrine hydrochloride) Injection, 10 mg/mL at 20°C to 25°C (68°F to 77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Protect from light. Store in carton until time of use. The 1 mL vials are for single use only; the 5 and 10 mL vials are pharmacy bulk packages.
The diluted solution should not be held for more than 4 hours at room temperature or for more than 24 hours under refrigerated conditions. Discard any unused portion.
Patient Counseling Information
If applicable, inform patient, family member, or caregiver that certain medical conditions and medications might influence how Vazculep (phenylephrine hydrochloride) Injection works.
Manufactured for:
Avadel Legacy Pharmaceuticals, LLC
Chesterfield, MO 63005
Rev. 02/17