Vanoxide-HC

Frequency Not Defined

Benzoyl Peroxide

• Irriation
• Contact dermatitis
• Dryness
• Erythema
• Stinging
• Peeling

Hydrocortisone

• Acneform eruptions
• Allergic contact dermatitis
• Skin atrophy
• Burning
• Dryness
• Folliculitis
• Hypertrichosis
• Hypopigmentation
• Itching
• Irritation
• Miliaria
• Perioral dermatitis
• Secondary infection
• Striae

Mechanism of Action

Benzoyl Peroxide

• Elicits action by releasing active oxygen
• Effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones
• Elicits keratolytic and desquamative effect, which may contribute to its efficacy

Hydrocortisone

• Decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes
• Inhibits macrophage accumulation in inflamed areas
• Reduces leukocyte adhesion to capillary endothelium
• Reduces capillary wall permeability and edema formation
• Decreases complement components and antagonizes histamine activity and release of kinin from substrates
• Reduces fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Pharmacokinetics

Benzoyl peroxide

• Absorbed by the skin where it is converted to benzoic acid

Hydrocortisone

• Percutaneous absorption of topical steroids increased by occlusive dressing

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• If you have an allergy to benzoyl peroxide, hydrocortisone, or any other part of Vanoxide-HC (benzoyl peroxide and hydrocortisone).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have a viral skin problem like chickenpox or shingles.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Vanoxide-HC with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Throw away any part not used after 3 months.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dry skin.
• Skin irritation.
• Itching.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Applies to benzoyl peroxide / hydrocortisone topical: topical kit, topical lotion

Local

Local side effects are the most common with benzoyl peroxide and have included excessive drying and contact dermatitis.

Local adverse effects of hydrocortisone may include burning, itching, or irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria especially if applied to denuded skin or with occlusive dressings.[Ref]

Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical steroids.

Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis has occasionally been reported.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.[Ref]

Hypersensitivity

Hypersensitivity reactions have included allergic sensitization in 1% to 5% of patients treated with benzoyl peroxide.[Ref]

Endocrine

Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.[Ref]

Some side effects of Vanoxide-HC may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.