Trimethobenzamide

Dosage Forms & Strengths

capsules

• 300mg

injectable solution

• 100mg/mL

Emesis

300 mg PO q6-8hr OR

200 mg IM q6-8hr

Renal Impairment

CrCl<70 mL/min: Consider a lower dose

Dosage Forms & Strengths

capsules

• 300mg

Emesis

20 mg/kg/day PO divided q6-8hr

Consider lower initial dose

Emesis

300 mg PO q6-8hr OR

200 mg IM q6-8hr  

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol. It may increase certain side effects of trimethobenzamide.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using trimethobenzamide and call your doctor at once if you have:

• twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

• trouble speaking or swallowing;

• pain, stiffness, or unusual muscle spasm in your neck;

• tremors, feeling restless or being unable to sit still;

• a seizure (convulsions); or

• jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

• headache, muscle cramps;

• dizziness, drowsiness;

• confusion, depressed mood;

• blurred vision; or

• diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Nausea/Vomiting:

-Oral: 300 mg orally 3 or 4 times a day
-Injection: 200 mg IM 3 or 4 times a day

Comments: Dosage should be adjusted according to the therapy indication, symptom severity, and patient response.

Use: Treatment of postoperative nausea and vomiting, and nausea associated with gastroenteritis.

Usual Pediatric Dose for Nausea/Vomiting:

-Oral: The manufacturer gives no specific dosing instructions; Caution recommended.
-Injection: Contraindicated

Comments: This drug should be avoided in children whose signs and symptoms could represent Reye's syndrome.

Use: Treatment of postoperative nausea and vomiting, and nausea associated with gastroenteritis.

It is very important that your doctor check your progress at regular visits to make sure that trimethobenzamide is working properly. Blood and urine tests may be needed to check for unwanted effects.

Trimethobenzamide will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds, sedatives, tranquilizers, sleeping medicines, prescription or narcotic pain medicines, barbiturates or seizure medicines, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide.

trimethobenzamide may cause extrapyramidal symptoms. Check with your doctor right away if you have difficulty in speaking, drooling, loss of balance control, muscle trembling, jerking, or stiffness, restlessness, shuffling walk, stiffness of the limbs, twisting movements of the body, or uncontrolled movements, especially of the face, neck, and back.

trimethobenzamide may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to trimethobenzamide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Trimethobenzamide hydrochloride is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

The injectable form of Trimethobenzamide hydrochloride is contraindicated in pediatric patients and in patients with known hypersensitivity to Trimethobenzamide.

Store between 20° to 25°C (68° to 77°F).
(See USP Controlled Room Temperature.)

Frequency not defined.

Cardiovascular: Hypotension (IV administration)

Central nervous system: Coma, depression, disorientation, dizziness, drowsiness, extrapyramidal reaction, headache, opisthotonos, Parkinsonian-like symptoms, seizure

Dermatologic: Allergic skin reaction

Gastrointestinal: Diarrhea

Hematologic & oncologic: Hematologic disease

Hepatic: Jaundice

Hypersensitivity: Hypersensitivity reaction

Local: Burning sensation at injection site, erythema at injection site, pain at injection site, swelling at injection site

Neuromuscular & skeletal: Muscle cramps

Ophthalmic: Blurred vision