Triprolidine

Triprolidine is used in the treatment of:

• Conjunctivitis, Allergic
• Dermatitis, Atopic

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Triprolidine is part of the drug class:

• Other antihistamines for systemic use

This is not a complete list of Triprolidinedrug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Triprolidine falls into category C:

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

OR

There are no well-controlled studies that have been done in pregnant women. Triprolidine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

OR

No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Triprolidine should be given to a pregnant woman only if clearly needed.

(trye PROE li deen)

• Triprolidine HCl
• Triprolidine Hydrochloride

• Alkylamine Derivative
• Histamine H1 Antagonist
• Histamine H1 Antagonist, First Generation

Triprolidine is an H1-receptor antagonist, which provides dose-related suppression of histamine-induced wheel and flare reactions (Simmons 1986). It is useful for the prevention and suppression of the signs and symptoms of allergic rhinitis and other upper respiratory allergies.

Metabolism

Extensively hepatic (Simons 1986)

Excretion

Urine (~1% as unchanged triprolidine) (Simons 1986)

Time to Peak

~2 hours (Simons 1986)

Half-Life Elimination

~2 hours (Simons 1986)

Upper respiratory allergies: Temporary relief of runny nose; sneezing; itchy nose and throat; and itchy, watery eyes caused by hay fever (allergic rhinitis) or other upper respiratory allergies.

Upper respiratory allergies: Oral:

Triprolidine 0.625 mg/mL:

Children 6 to <12 years: 1.25 mg every 6 hours (maximum: 5 mg/day)

Children ≥12 years and Adolescents: 2.5 mg every 6 hours (maximum: 10 mg/day)

Triprolidine 0.938 mg/mL:

Infants and Children 4 months to <2 years: 0.31 mg (0.33 mL) every 4 to 6 hours (maximum: 1.25 mg/day)

Children 2 to <4 years: 0.63 mg (0.67 mL) every 4 to 6 hours (maximum: 2.5 mg/day)

Children 4 to <6 years: 0.938 mg (1 mL) every 4 to 6 hours (maximum: 3.75 mg/day)

Triprolidine 1.25 mg/mL:

Infants and Children 4 months to <2 years: 0.31 mg (0.25 mL) every 4 to 6 hours (maximum: 1.25 mg/day)

Children 2 to <4 years: 0.63 mg (0.5 mL) every 4 to 6 hours (maximum: 2.5 mg/day)

Children 4 to <6 years: 0.938 (0.75 mL) every 4 to 6 hours (maximum: 3.75 mg/day)

Triprolidine 2.5 mg/5 mL:

Children 6 to <12 years: 1.25 mg every 4 to 6 hours (maximum: 5 mg/day)

Children ≥12 years and Adolescents: 2.5 mg every 4 to 6 hours (maximum: 10 mg/day)