Trazodone

Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. The major neurotransmitters are acetylcholine, norepinephrine, dopamine and serotonin. Many experts believe that an imbalance among the different neurotransmitters is the cause of depression. Although the exact mechanism of action of trazodone is unknown, it probably improves symptoms of depression by inhibiting the uptake of serotonin by nerves in the brain. This results in more serotonin to stimulate other nerves. Trazodone also may increase directly the action of serotonin. Trazodone is chemically unrelated to the selective serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). It is chemically related to nefazodone (Serzone) and shares its actions. Trazodone was approved by the FDA in 1982.

There are no adequate studies of trazodone in pregnant women. Studies in animals have demonstrated effects on the developing fetus. Trazodone should only be used during pregnancy if the physician feels that its benefits outweigh its potential risks.

Trazodone is secreted in breast milk. Therefore, caution should be used in prescribing trazodone to women who are breastfeeding.

Trazodone is a prescription medication used to treat depression. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Trazodone may be found in some form under the following brand names:

• Desyrel

• Oleptro

Trazodone is part of the drug class:

• Other antidepressants

Tell your doctor if you are allergic to any ingredient in trazodone.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if trazodone is excreted in human breast milk or if it will harm your nursing baby.

Take trazodone exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.

• Immediate-release tablet: 150 mg/day in divided doses is suggested. The dose may be increased by 50 mg/day every 3 to 4 days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses. Inpatients (more severely depressed patients) may be given up to but not in excess of 600 mg/day in divided doses.
• Extended-release tablet: 150 mg once daily. May be increased by 75 mg per day every three days. Maximum dose: 375 mg per day.

Trazodone hydrochloride tablets, USP are available as follows:

Trazodone hydrochloride tablets, USP 50 mg are scored, white, film coated, round, debossed MP 118

Trazodone hydrochloride tablets, USP 100 mg are scored, white, film coated, round, debossed MP 114

Trazodone hydrochloride tablets, USP 150 mg are scored in the divided dose design, white, round, debossed on one side and MP 168 on the reverse side.

Store at 20° to 25°C (68° to 77°F).

[See USP Controlled Room Temperature]

DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.

• Oleptro [DSC]