Ticarcillin Clavulanate

Name: Ticarcillin Clavulanate

Ticarcillin Clavulanate 200 mg
Ticarcillin Clavulanate used to treat

Administration

IV Incompatibilities

Additive: sodium bicarbonate, aminoglycosides, ciprofloxacin(?)

Y-site: alatrofloxacin, amphotericin B cholesteryl sulfate, azithromycin, cisatracurium(?), topotecan(?), vancomycin(?)

IV Compatibilities

Solution: compatible w/ most common solvents

Y-site: (partial list) allopurinol, clarithromycin, diltiazem, fluconazole, heparin, meperidine, morphine, ondansetron, propofol

IV Preparation

Reconstitute 3.1 g vial with 13 mL SWI or NS; final concentration 200 mg/6.7 mg/mL

For intermittent IV infusion, further dilute to 10-100 mg/mL (ticarcillin component with compatible IV solution

Bulk vial 30 g/1 g

Not for direct infusion
Reconstitute with 76 mL SWI or NS; final concentration 300 mg/10 mg/mL
Further dilute before administration to 10-100 mg/mL (ticarcillin component)

IV Administration

Intermittent IV infusion over 30 min

Administer 1 hr apart from aminoglycosides

Storage

Reconstituted solution is stable for 6 hr at room temperature and 72 hr when refrigerated

IV infusion in NS is stable for 24 hr at room temperature and 7 days when refrigerated, or 30 days when frozen

Darkening indicates loss of potency

What Is Ticarcillin Clavulanate?

Ticarcillin is a penicillin antibiotic that fights bacteria in the body.

Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that are often resistant to penicillins and other antibiotics.

Ticarcillin and clavulanate potassium is a combination medicine used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, stomach infections, skin infections, and others.

Ticarcillin and clavulanate potassium may also be used for purposes not listed in this medication guide.

You should not use this medication if you are allergic to any penicillin or cephalosporin antibiotic.

You should not use this medication if you are allergic to ticarcillin or clavulanate potassium, or if you are allergic to:

a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others; or
a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), ticarcillin (Ticar, Timentin), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).

To make sure ticarcillin and clavulanate potassium is safe for you, tell your doctor if you have:

kidney disease;
a bleeding or blood clotting disorder;
an electrolyte imbalance such as low levels of potassium in your blood;
a history of any type of allergy; or
if you are on a low-salt diet.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Ticarcillin and clavulanate potassium can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ticarcillin and clavulanate potassium.

It is not known whether ticarcillin and clavulanate potassium passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.