Technetium Tc 99m Generator For Diagnostic Use

The Technelite generator is a source of sodium pertechnetate Tc 99m for use in the preparation of FDA-approved diagnostic radiopharmaceuticals, as described in the labeling of these diagnostic radiopharmaceutical kits.

Sodium Pertechnetate Tc 99m Injection is used IN ADULTS as an agent for:

• Thyroid Imaging
• Salivary Gland Imaging
• Urinary Bladder Imaging (direct isotopic cystography) for the detection of vesico-ureteral reflux.
• Nasolacrimal Drainage System Imaging (dacryoscintigraphy)

Sodium Pertechnetate Tc 99m Injection is used IN CHILDREN as an agent for:

• Thyroid Imaging
• Urinary Bladder Imaging (direct isotopic cystography) for the detection of vesico-ureteral reflux.

No information provided.

The pertechnetate ion distributes in the body similarly to the iodide ion but is not organified when trapped in the thyroid gland. It also concentrates in the choroid plexus, thyroid gland, salivary glands, and stomach. However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid gland.

After intravascular administration the pertechnetate ion gradually equilibrates with the extracellular space. A fraction is promptly excreted via the kidneys.

Following the administration of Sodium Pertechnetate Tc 99m Injection as an eye drop, the drug mixes with tears within the conjunctival space. Within seconds to minutes it leaves the conjunctival space and escapes into the inferior meatus of the nose through the nasolacrimal drainage system. During this process the pertechnetate ion passes through the canaliculi, the lacrimal sac and the nasolacrimal duct. In the event of any anatomical or functional blockage of the drainage system there will be a backflow resulting in tearing (epiphora). Thus the pertechnetate escapes the conjunctival space in the tears.

While the major part of the pertechnetate escapes within a few minutes of normal drainage and tearing, it has been documented that there is some degree of transconjunctival absorption with a fractional turnover rate of 0.015/min in normal individuals, 0.021/min in patients without any sac and 0.027/min in patients with inflamed conjunctiva due to chronic dacryocystitis. Individual values may vary but these rates are probably representative and indicate that the maximum possible pertechnetate absorbed will remain below one thousandth of that used in other routine diagnostic procedures.

Allergic reactions including anaphylaxis have been reported infrequently following the administration of Sodium Pertechnetate Tc 99m Injection.

Read the entire FDA prescribing information for TechneLite (Technetium Tc 99m Generator For Diagnostic Use)

• Ultra-TechneKow

© TechneLite Patient Information is supplied by Cerner Multum, Inc. and TechneLite Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.