- Sotradecol uses
- Sotradecol used to treat
- Sotradecol sotradecol drug
- Sotradecol drug
- Sotradecol injection
- Sotradecol side effects
- Sotradecol 20 mg
- Sotradecol sotradecol dosage
- Sotradecol dosage
- Sotradecol side effects of sotradecol
- Sotradecol effects of sotradecol
Uses of Sotradecol
Sotradecol is a prescription medication used to treat varicose veins.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Sotradecol Drug Class
Sotradecol is part of the drug class:
Sclerosing agents for local injection
Sotradecol (sodium tetradecyl sulfate) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; sneezing, runny nose, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain or swelling in one or both legs;
chest pain, sudden cough, wheezing, rapid breathing, fast heart rate; or
pain, itching, peeling, skin sores, or skin changes where the medicine was injected.
Common side effects may include:
nausea, vomiting; or
discolored skin along the treated vein (may be permanent).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sclerosing agent; anionic surfactant and detergent.1 2 3 7
Interactions for Sotradecol
No well-controlled interaction studies in patients receiving antiovulatory agents;1 fatality reported in patient receiving an antiovulatory agent at the time of sodium tetradecyl sulfate treatment1
Evaluate and use clinical judgment prior to sodium tetradecyl sulfate treatment in patients receiving antiovulatory agents1
Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. The structural formula is as follows:
C14H29NaSO4 7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt MW 316.44
Sotradecol (sodium tetradecyl sulfate injection) is a sterile nonpyrogenic solution for intravenous use as a sclerosing agent.
1% 20 mg/2 mL (10 mg/mL): Each mL contains sodium tetradecyl sulfate 10 mg, benzyl alcohol 0.02 mL and dibasic sodium phosphate, anhydrous 4.0 mg in Water for Injection. pH 7.9; monobasic sodium phosphate and/or sodium hydroxide added, if needed, for pH adjustment.
3% 60 mg/2 mL (30 mg/mL): Each mL contains sodium tetradecyl sulfate 30 mg, benzyl alcohol 0.02 mL and dibasic sodium phosphate, anhydrous 9.0 mg in Water for Injection. pH 7.9; monobasic sodium phosphate and/or sodium hydroxide added, if needed, for pH adjustment.
Sotradecol - Clinical Pharmacology
Sotradecol (sodium tetradecyl sulfate injection) is a sclerosing agent. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.
Indications and Usage for Sotradecol
Sotradecol (sodium tetradecyl sulfate injection) is indicated in the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. The benefit-to-risk ratio should be considered in selected patients who are great surgical risks.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Sotradecol is administered to a nursing woman.
Sotradecol Dosage and Administration
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use if precipitated or discolored.
Sotradecol (sodium tetradecyl sulfate injection) is for intravenous use only. The strength of solution required depends on the size and degree of varicosity. In general, the 1% solution will be found most useful with the 3% solution preferred for larger varicosities. The dosage should be kept small, using 0.5 mL to 2 mL (preferably 1 mL maximum) for each injection, and the maximum single treatment should not exceed 10 mL.
How is Sotradecol Supplied
Sotradecol® (sodium tetradecyl sulfate injection)
carton containing 5, 2 mL vials with 1% 20 mg/2 mL (10 mg/mL)
carton containing 5, 2 mL vials with 3% 60 mg/2 mL (30 mg/mL)
For Healthcare Professionals
Applies to sodium tetradecyl sulfate: injectable solution
Local side effects have included pain and urticaria or ulceration at the injection site. A permanent discoloration along the path of the sclerosed vein segment has also been reported.[Ref]
Four cases of anaphylactic shock leading to death have been reported in patients receiving sodium tetradecyl sulfate (the active ingredient contained in Sotradecol) Of these four patients, one had a history of asthma.[Ref]
Hypersensitivity side effects have included hives, asthma, hayfever, and anaphylactic shock.[Ref]
Gastrointestinal side effects have included nausea and vomiting.[Ref]
General side effects have included headache.[Ref]
Some side effects of Sotradecol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.