Sonahist

Sonahist is part of the drug classes:

• Substituted alkylamines

• Adrenergic and dopaminergic agents

• Sympathomimetics

• Sympathomimetics excl. antiglaucoma preparations

• Sympathomimetics used as decongestants

• Sympathomimetics, combinations excl. corticosteroids

• Sympathomimetics, plain

Children 6 to under 12 years of age: 2 dropperfuls (2 mL) every 4-6 hours; Children 2 to under 6 years of age: 1 dropperful (1 mL) every 4-6 hours; Children under 2 years of age: As directed by a physician.

Sonahist Pediatric Drops is supplied as clear, orange-vanilla flavored pediatric drops. Each dropperful (1 mL) contains: 1 mg chlorpheniramine maleate; 2 mg phenylephrine hydrochloride.

Sonahist is contraindicated in patients with hypersensitivity or idiosyncrasy to any of its ingredients, patients taking monoamine oxidase (MAO) inhibitors or for two weeks after stopping the MAOI drug, patients with narrow-angle glaucoma, severe coronary artery disease, urinary retention, peptic ulcer, severe hypertension, patients with breathing problems such as emphysema or chronic bronchitis, or nursing mothers.

Overdosage with sympathomimetic amines can cause hypertension, headache, convulsions, cerebral hemorrhage and vomiting may occur. Premature ventricular beats and short paroxysms of ventricular tachycardia may also occur. Headache may be a symptom of hypertension. Bradycardia may also be seen early in Phenylephrine HCI overdosage through stimulation of baroreceptors. Excessive CNS stimulation may result in excitement tremor, restlessness, and insomnia. Other effects may include pallor mydriasis, hyperglycemia, and urinary retention. Severe overdosage may cause tachypnea or hypernea, hallucinations, convulsions, or delirium, but in some individuals, there may be CNS depression. Arrhythmias (including ventricular fibrillation) may lead to hypotension and circulatory collapse. Severe hypokalemia can occur, probably due to a compartmental shift rather than a depletion of potassium.

Should sympathomimetic symptoms predominate, central action constitutes the greatest danger. In the small child, symptoms include excitability, hallucination, ataxia, incoordination, tremors, flushed face and fever. Convulsion, fixed and dilated pupils, coma and death may occur in severe cases. In the adult, fever and flushing are uncommon, excitement leading to convulsions and postictal depression is often proceeded by drowsiness and coma. Respiration is usually not seriously depressed; blood pressure is usually stable.

Treatment: The patient should be induced to vomit, even if emesis has occurred spontaneously. Pharmacologic vomiting by the administration of ipecac syrup is a preferred method, however, vomiting should not be induced in patients with impaired consciousness. Precautions against aspiration must be taken, especially in infants and children. Following emesis, any drug remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water. Treatment of the signs and symptoms of overdosage is symptomatic and supportive.

Applies to chlorpheniramine / phenylephrine: oral liquid, oral syrup, oral tablet