Sodium zirconium cyclosilicate

• Lokelma

1 hour

Hyperkalemia: Treatment of hyperkalemia in adults.

Limitations of use: Should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.

Clopidogrel: Sodium Zirconium Cyclosilicate may decrease serum concentrations of the active metabolite(s) of Clopidogrel. Management: Separate the administration of sodium zirconium cyclosilicate and clopidogrel by at least 2 hours. Consider therapy modification

Dabigatran Etexilate: Sodium Zirconium Cyclosilicate may decrease the serum concentration of Dabigatran Etexilate. Management: Separate the administration of sodium zirconium cyclosilicate and dabigatran by at least 2 hours. Consider therapy modification

Warfarin: Sodium Zirconium Cyclosilicate may increase the serum concentration of Warfarin. Management: Separate the administration of sodium zirconium cyclosilicate and warfarin by at least 2 hours. If simultaneous administration is required, monitor for signs and symptoms of warfarin toxicity (eg, elevated INR, bleeding). Consider therapy modification

>10%: Cardiovascular: Edema (4% to 16%), peripheral edema (8% to 11%)

1% to 10%: Endocrine & metabolic: Hypokalemia (4%)

Serum potassium; signs/symptoms of edema

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Use sodium zirconium cyclosilicate as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Mix the contents of the packet in a glass with about 3 tablespoons (45 mL) or more of water. Stir well and drink right away.
• If there is powder in the glass after taking your dose, add more water, stir, and drink right away. Do this until there is no more powder.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Sodium zirconium cyclosilicate is a potassium-removing agent.

Specific Drugs

It is essential that the manufacturer's labeling be consulted for more detailed information on interactions with this drug, including possible dosage adjustments. Interaction highlights:

In general, other oral medications should be administered at least 2 hours before or 2 hours after sodium zirconium cyclosilicate.1

Sodium zirconium cyclosilicate is used to treat hyperkalemia (high potassium in the blood). Sodium zirconium cyclosilicate is a potassium binder. It should not be used as an emergency treatment for life-threatening hyperkalemia.

Sodium zirconium cyclosilicate is available only with your doctor's prescription.

It is very important that your doctor check your progress at regular visits to make sure that sodium zirconium cyclosilicate is working properly and to check for unwanted effects.

Sodium zirconium cyclosilicate may cause swelling in the different parts of your body. This is more likely if you have heart failure or kidney disease. You may also need to adjust your sodium intake while using sodium zirconium cyclosilicate. Talk to your doctor if you have any concerns.