Scullcap baikal skullcap
Name: Scullcap baikal skullcap
What happens if I miss a dose?
Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra scullcap to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Uses
Scullcap traditionally has been used as a sedative for nervousness and anxiety, although there is little to no data to support any of these uses.
Contraindications
Contraindications have not yet been identified.
Chemistry
The various species of Scutellaria contain several flavonoid glycoside pigments. These include scutellarein, wogonin, isoscutellarein, and baicalin. A diterpenoid (scuterivulactone) has also been identified. 4
The aboveground parts of S. lateriflora have been found to contain neoclerodane diterpenes, 5 flavones, and flavone glucuronides. 6 The flavonoids include baicalin, lateriflorin, dihydrobaicalin, and baicalein, which were quantitatively determined by liquid chromagraphy with ultraviolet detection/MS, and thin-layer chromatography. Adulteration of S. lateriflora with species of germander was detected by microscopy and by the presence of phenylpropanoids such as teucreoside, which were not found in scullcap. 7
Bibliography
2. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med . 2003;9:74-78.
3. Tyler VE. The New Honest Herbal . 2nd ed. Philadelphia, PA: G.F. Stickley Co.; 1987.
4. Kizu H, Imoto Y, Tomimori T, Tsubono K, Kadota S, Kikuchi T. Structure of scuterivulactone D determined by two-dimensional NMR spectroscopy. A new diterpenoid from a Chinese crude drug “ban zhi lian” ( Scutellaria rivularis Wall.). Chem Pharm Bull . 1987;35:1656-1659.
5. Bruno M, Cruciata M, Bondi, ML, et al. Neo-clerodane diterpenoids from Scutellaria lateriflora . Phytochemistry . 1998;48:687.
6. Gafner S, Bergeron C, Batcha LL, et al. Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora . J Nat Prod . 2003;66:535-537.
7. Gafner S, Bergeron C, Batcha LL, et al. Analysis of Scutellaria lateriflora and its adulterants Teucrium canadense and Teucrium chamaedrys by LC-UV/MS, TLC, and digital photomicroscopy. J AOAC Int . 2003;86:453-460.
8. Awad R, Arnason JT, Trudeau V. Phytochemical and biological analysis of skullcap ( Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine . 2003;10:640-649.
9. Franzblau SG, Cross C. Comparative in vitro antimicrobial activity of Chinese medicinal herbs. J Ethnopharmacol . 1986;15:279-288.
10. Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG . 2002;109:227-235.
11. Duke JA. CRC Handbook of Medicinal Herbs . Boca Raton, FL: CRC Press; 1985.
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