Santyl

Mechanism of Action

Collagen-degrading enzyme; has high specificity for native and denatured collagen; digests collagen in necrotic tissue but not in healthy tissue; does not act on fibrin, fat, keratin or muscle

No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than one year with a combination of collagenase and cortisone has been reported.

No information provided.

Collagenase is an enzyme that breaks down collagen in damaged tissues within the skin and helps the body generate new healthy tissue. Collagen is a type of protein that connects and supports fibers in body tissues such as skin, tendons, muscles, and bone.

Collagenase topical (for the skin) is applied to severe burns or skin ulcers to help remove dead skin tissue and aid in wound healing.

Collagenase topical may also be used for other purposes not listed in this medication guide.

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions, and if you are pregnant or breast-feeding.

Apply this medication only to the affected skin wound. Try not to get any ointment on the healthy skin around the wound.

The enzymes in collagenase topical may increase your risk of a bacterial infection in your blood stream. Call your doctor at once if you have any signs of infection such as fever, chills, rapid heartbeats, nausea, vomiting, stomach pain, or feeling very ill.

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions, and if you are pregnant or breast-feeding.

Apply this medication only to the affected skin wound. Try not to get any ointment on the healthy skin around the wound.

The enzymes in collagenase topical may increase your risk of a bacterial infection in your blood stream. Call your doctor at once if you have any signs of infection such as fever, chills, rapid heartbeats, nausea, vomiting, stomach pain, or feeling very ill.

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions.

It is not known whether collagenase topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether collagenase topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avoid using other medications on the areas you treat with collagenase topical unless your doctor tells you to.

• If you have an allergy to collagenase or any other part of Santyl (collagenase (topical)).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Applies to collagenase topical: topical ointment

Side effects include:

Slight erythema.