Rifampin, Isoniazid, And Pyrazinamide (Oral Route)

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Artemether
• Atazanavir
• Boceprevir
• Cobicistat
• Daclatasvir
• Darunavir
• Dasabuvir
• Delamanid
• Elbasvir
• Elvitegravir
• Fosamprenavir
• Grazoprevir
• Isavuconazonium
• Lopinavir
• Lurasidone
• Maraviroc
• Nelfinavir
• Ombitasvir
• Paritaprevir
• Praziquantel
• Ranolazine
• Rilpivirine
• Ritonavir
• Saquinavir
• Telaprevir
• Tipranavir
• Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone
• Acetaminophen
• Afatinib
• Amiodarone
• Amprenavir
• Apixaban
• Apremilast
• Aprepitant
• Aripiprazole
• Atovaquone
• Axitinib
• Bedaquiline
• Bosutinib
• Brexpiprazole
• Brivaracetam
• Bupropion
• Cabozantinib
• Carbamazepine
• Cariprazine
• Ceritinib
• Cholera Vaccine, Live
• Clozapine
• Cobimetinib
• Crizotinib
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Dasatinib
• Deferasirox
• Delavirdine
• Digoxin
• Dolutegravir
• Domperidone
• Donepezil
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dronedarone
• Edoxaban
• Efavirenz
• Eliglustat
• Eluxadoline
• Enzalutamide
• Erlotinib
• Ethionamide
• Etravirine
• Everolimus
• Exemestane
• Fentanyl
• Fosaprepitant
• Fosphenytoin
• Gefitinib
• Glimepiride
• Hydrocodone
• Ibrutinib
• Idelalisib
• Ifosfamide
• Imatinib
• Indinavir
• Irinotecan
• Irinotecan Liposome
• Isoniazid
• Itraconazole
• Ivabradine
• Ivacaftor
• Ixabepilone
• Ixazomib
• Ketoconazole
• Lamotrigine
• Lapatinib
• Ledipasvir
• Levodopa
• Linagliptin
• Lorcainide
• Macitentan
• Manidipine
• Mifepristone
• Mycophenolate Mofetil
• Mycophenolic Acid
• Naloxegol
• Netupitant
• Nevirapine
• Nifedipine
• Nilotinib
• Nimodipine
• Nintedanib
• Olaparib
• Osimertinib
• Palbociclib
• Panobinostat
• Pazopanib
• Perampanel
• Phenytoin
• Piperaquine
• Pitavastatin
• Pixantrone
• Ponatinib
• Posaconazole
• Pyrazinamide
• Quetiapine
• Quinine
• Regorafenib
• Rifampin
• Rivaroxaban
• Roflumilast
• Rolapitant
• Romidepsin
• Simeprevir
• Sirolimus
• Sofosbuvir
• Sonidegib
• Sorafenib
• Sunitinib
• Tacrolimus
• Tasimelteon
• Tegafur
• Telithromycin
• Temsirolimus
• Tenofovir Alafenamide
• Ticagrelor
• Tofacitinib
• Tolvaptan
• Trabectedin
• Ulipristal
• Vandetanib
• Velpatasvir
• Vemurafenib
• Venetoclax
• Vilazodone
• Vincristine
• Vincristine Sulfate Liposome
• Vinflunine
• Vorapaxar
• Vortioxetine
• Zidovudine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetyldigoxin
• Aliskiren
• Aminosalicylic Acid
• Anisindione
• Atorvastatin
• Betamethasone
• Bexarotene
• Bosentan
• Buspirone
• Carbamazepine
• Carvedilol
• Caspofungin
• Chloramphenicol
• Chlorpropamide
• Citalopram
• Clarithromycin
• Clofibrate
• Cortisone
• Desogestrel
• Dexamethasone
• Diazepam
• Dicumarol
• Dienogest
• Diltiazem
• Disopyramide
• Disulfiram
• Doxycycline
• Drospirenone
• Eltrombopag
• Enalaprilat
• Enalapril Maleate
• Enflurane
• Estradiol Cypionate
• Estradiol Valerate
• Ethinyl Estradiol
• Ethynodiol Diacetate
• Etonogestrel
• Etoricoxib
• Fesoterodine
• Fluconazole
• Fludrocortisone
• Fosphenytoin
• Gliclazide
• Glyburide
• Haloperidol
• Isradipine
• Levomethadyl
• Levonorgestrel
• Levothyroxine
• Linezolid
• Losartan
• Mefloquine
• Meperidine
• Mestranol
• Metformin
• Methadone
• Methylprednisolone
• Metoprolol
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nisoldipine
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Ospemifene
• Oxycodone
• Phenprocoumon
• Phenytoin
• Pioglitazone
• Pirmenol
• Prednisolone
• Prednisone
• Propafenone
• Raltegravir
• Repaglinide
• Rofecoxib
• Rosiglitazone
• Sertraline
• Simvastatin
• Tadalafil
• Tamoxifen
• Theophylline
• Tocainide
• Triazolam
• Trimetrexate
• Valproic Acid
• Warfarin
• Zaleplon
• Zidovudine

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• food
• Tyramine Containing Food

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, or history of—Use with caution. There may be an increased chance of getting hepatitis if you take this medicine and drink alcohol daily.

• Diabetes, history of or
• Porphyria (an enzyme problem)—Use with caution. May make these conditions worse.

• Gout, acute or
• Liver disease, acute or severe—Should not be used in patients with these conditions.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If rifampin, isoniazid, and pyrazinamide combination is taken on an irregular schedule, side effects may occur more often and may be more serious than usual. If you have any questions about this, check with your doctor.