Quinupristin/dalfopristin

IV Incompatibilities

Solution: NaCl-containing diluents

IV Compatibilities

Y-site: aztreonam, ciprofloxacin, fenoldopam, fluconazole, haloperidol, metoclopramide, KCl

IV Preparation

Reconstitute 500 mg-containing vial with 5 mL of D5W or SWI to obtain 100 mg/mL solution

Do not shake; swirl gently to dissolve while limiting foam formation

Dilute reconstituted solution within 30 min

Reconstituted solution should be added to at least 250 mL of D5W for peripheral administration (increase to 500 mL or 750 mL if necessary to limit venous irritation). Final conc NMT 2 mg/mL

An infusion volume of 100 mL may be used for central line infusions

Do not freeze solution

IV Administration

Flush with D5W before and after administration; incompatible with saline

Complete infusion over 1 hr (toxicity may be increased with shorter infusion)

If severe venous irritation occurs following peripheral administration of quinupristin/dalfopristin diluted in 250 mL D5W, consider increasing the infusion volume to 500 mL or 750 mL, changing the infusion site, or infusing by a peripherally inserted central catheter (PICC) or a central venous catheter

Storage

Refrigerate unopened vials