Pileran

Metoclopramide is a prescription medicine used to:

• treat gastroesophageal reflux disease (GERD) when certain other treatments do not work (short-term)
• relieve symptoms of slow stomach emptying in people with diabetes
• prevent nausea and vomiting that can happen with cancer chemotherapy
• prevent nausea and vomiting that may happen after surgery, if your doctor decides that you should not be treated with a stomach tube and suction
• help make it easier to insert a tube into the small intestine, if the tube does not pass into the stomach normally
• help empty stomach contents or to help barium move through your intestine, when you get an X-ray examination of the stomach or small intestine

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• another medicine that contains metoclopramide
• a blood pressure medicine
• a medicine for depression, especially Monoamine Oxidase Inhibitors (MAOI's) such as tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), and rasagiline (Azilect)
• insulin
• a medicine that can make you sleepy, such as anti-anxiety medicine, tranquilizers, sedatives, hypnotics, sleep medicines, and narcotics
• digoxin (Lanoxin)
• acetaminophen (Tyelnol)
• tetracycline
• levodopa
• alcohol
• cyclosporine (Neoral, Sandimmune, Gengraf)

Metoclopramide can affect how fast your food will be delivered to your intestines, so the timing and dosage of insulin may needs to be adjusted.

If you are not sure if your medicine is one listed above, ask your doctor or pharmacist.

Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.

Metoclopramide can cause serious side effects, including:

Serious side effects have been reported including:

• Abnormal muscle movements called tardive dyskinesia (TD). These movements happen mostly in the face muscles. You can not control these movements. They may not go away even after stopping metoclopramide. There is no treatment for TD, but symptoms may lessen or go away over time after you stop taking metoclopramide.

Your chances for getting TD go up:

• the longer you take metoclopramide and the more metoclopramide you take. You should not take metoclopramide for more than 12 weeks.
• if you are older, especially if you are a woman
• if you have diabetes

It is not possible for your doctor to know if you will get TD if you take metoclopramide.

Call your doctor right away if you get movements you can not stop or control, such as:

• lip smacking, chewing, or puckering up your mouth
• frowning or scowling
• sticking out your tongue
• blinking and moving your eyes
• shaking of your arms and legs

• Uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia). These muscle spasms can cause abnormal movements and body positions. These spasms usually start within the first 2 days of treatment. These spasms happen more often in children and adults under age 30.
• Depression, thoughts about suicide, and suicide. Some people who take metoclopramide become depressed. You may have thoughts about hurting or killing yourself. Some people who take metoclopramide have ended their own lives (suicide).

• Neuroleptic Malignant Syndrome (NMS). NMS is a very rare but very serious condition that can happen with metoclopramide. NMS can cause death and must be treated in a hospital. Symptoms of NMS include: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating.
• Parkinsonism. Symptoms include slight shaking, body stiffness, trouble moving or keeping your balance. If you already have Parkinson's disease, your symptoms may become worse while you are receiving metoclopramide.

Call your doctor and get medical help right away if you:

• feel depressed or have thoughts about hurting or killing yourself
• have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating
• have muscle movements you cannot stop or control
• have muscle movements that are new or unusual

Do not drink alcohol while receiving metoclopramide injection. Alcohol may make some side effects of metoclopramide injection worse, such as feeling sleepy.

Do not drive, work with machines, or do dangerous tasks until you know how metoclopramide injection affects you. Metoclopramide injection may cause sleepiness.

Do not take metoclopramide if you:

• have stomach or intestine problems that could get worse with metoclopramide, such as bleeding, blockage or a tear in the stomach or bowel wall
• have an adrenal gland tumor called a pheochromocytoma
• are allergic to metoclopramide or anything in it
• take medicines that can cause uncontrolled movements, such as medicines for mental illness
• have seizures

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of metoclopramide there are no specific foods that you must exclude from your diet when receiving this medication.

Metoclopramide has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from metoclopramide, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

If you take too much metoclopramide, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If metoclopramide is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.