Pro-Med

Name: Pro-Med

Pro-Med Overview

Promethazine is a prescription medication used to treat allergic reactions and nausea. Promethazine belongs to a group of drugs called antihistamines. It blocks the effect of histamine, a chemical in the body that causes symptoms of allergic reactions. Promethazine also belongs to another group of drugs called antiemetics, which reduce feelings of nausea.

Promethazine comes as a tablet, oral solution (liquid), rectal suppository, and a liquid to be injected into a muscle.  It is usually taken once daily at bedtime or before meals every six to twelve hours as needed to relieve symptoms of allergy or nausea. 

Common side effects of promethazine include blurred vision, and dry mouth. It can also cause dizziness and drowsiness. Do not drive or operate heavy machinery until you know how promethazine affects you. Limit alcoholic beverages.  

Side Effects of Pro-Med

Serious side effects have been reported with promethazine.  See "Drug Precautions" section.

Common side effects of promethazine include:
  • dizzness
  • drowsiness
  • blurred vision
  • confusion
  • dry mouth
This is not a complete list of promethazine side effects.  Ask your doctor or pharmacist for more information. Call your doctor for medical advice about side effects.  You may report side effects to the FDA at 1-800-FDA-1088.

Pro-Med and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.  It is not known if promethazine is excreted in human breast milk or if it will harm your nursing baby.

 

Pro-Med Overdose

If you take too much promethazine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

 

Other Requirements

Store promethazine rectal suppositories in a refrigerator between 36 - 46°F.

Store promethazine tablets, oral solution, and solution for injection at room temperature between 68 - 77°F and protect from light.

Pro-Med FDA Warning

Promethazine should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine in pediatric patients less than 2 years of age. Caution should be exercised when administering Promethazine to pediatric patients 2 years of age and older.

Promethazine Injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration. Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required.

Due to the risks of intravenous injection, the preferred route of administration of Promethazine Injection is deep intramuscular injection. Subcutaneous injection is contraindicated

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