Neomycin Sulfate

Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin sulfate. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity.

Hemodialysis will remove neomycin sulfate from the blood.

If you are being treated for hepatic coma, avoid eating foods that are high in protein. Follow your doctor's instructions about any other restrictions on food, beverages, or activity.

Your doctor or pharmacist can provide more information about neomycin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Storage

Oral

20–25°C in tight container.2

15–30°C.1

• Usually bactericidal.1 2 b

• Inhibits protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits.b

• Following oral administration, rapidly suppresses growth of most intestinal bacteria; these are replaced by nonpathogenic yeasts and, occasionally, resistant strains of Enterobacter aerogenes.1 2 Suppression persists for 48–72 hours after the dose.1 2

• In vitro spectrum of activity includes many gram-negative aerobic bacteria and some aerobic gram-positive bacteria.1 2 Inactive against fungi,b viruses,b and most anaerobic bacteria.1 2 b

• Gram-negative aerobes: Active in vitro against Enterobacter, Escherichia coli, and Klebsiella.1 2

• Partial cross-resistance occurs between neomycin and other aminoglycosides.b

Neomycin Sulfate Tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete Streptomyces fradiae. Structurally, Neomycin Sulfate may be represented as follows:

Chemically, it is O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→  3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2, 6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine. Neomycin B is identical except that the α-D-glucopyranosyl residue in the neobiosamine moiety is β-L-idopyranosyl.

Each tablet contains 500 mg Neomycin Sulfate (equivalent to 350 mg neomycin base).

Inactive Ingredients: Calcium Stearate, Colloidal Silicon Dioxide, Povidone.

Neomycin Sulfate TABLETS USP, 500 MG

NDC 51991-738-01