Neomycin Sulfate topical

Name: Neomycin Sulfate topical

Introduction

Aminoglycoside antibiotic.a

Neomycin Sulfate Pharmacokinetics

Absorption

Bioavailability

Not absorbed to any appreciable extent from intact skin.a Readily absorbed through denuded or abraded areas of skin or skin that has lost the keratin layer (i.e., wounds, burns, ulcers).a Rapidly absorbed from the peritoneum, draining sinuses, wounds, or surgical sites.a

Plasma Concentrations

Plasma concentrations following topical application to open wounds, burns, or granulating surfaces comparable to, or higher than, those achieved following oral or parenteral administration (parenteral preparation no longer commercially available in the US).b

Stability

Storage

Topical

Cream/Ointment

Light resistant containers at 15–30°C.a

Bladder Irrigation

Solution for Irrigation

2–8°C.b

Following dilution for administration, store at 4°C; use within 48 hours.b

Actions and Spectrum

  • Usually bactericidal.a

  • Appears to inhibit protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits.a

  • Spectrum of activity includes many aerobic gram-negative bacteria and some aerobic gram-positive bacteria.a

  • Gram-positive aerobes: Active against Staphylococcus aureus and S. epidermidis.a Most streptococci are resistant.a

  • Gram-negative aerobes: Active against Escherichia coli, Haemophilus influenzae, Klebsiella, Neisseria, Moraxella lacunata, and Proteus.a b Inactive against Serratia marcescensb and Pseudomonas aeruginosa.a

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