Muromonab-Cd3 (Intravenous Route)

Muromonab-CD3 is a monoclonal antibody. It is used to reduce the body's natural immunity in patients who receive organ (for example, kidney) transplants.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Muromonab-CD3 works by preventing the white blood cells from doing this.

The effect of muromonab-CD3 on the white blood cells may also reduce the body's ability to fight infections. Before you begin treatment, you and your doctor should talk about the good this medicine will do as well as the risks of using it.

Muromonab-CD3 is to be administered only by or under the immediate supervision of your doctor.

This product is available in the following dosage forms:

• Solution

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (chest pain) or
• Circulation problems or
• Convulsions (seizures) or
• Heart attack (recent) or
• Heart problems, other, or
• Kidney problems or
• Lung problems or
• Nervous system problems—Increased risk of serious unwanted effects from muromonab-CD3

• Blood clots (history of)—Risk of blood clots in transplanted organ or blood vessels

• Chickenpox (including recent exposure) or
• Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body

• Infection—Muromonab-CD3 decreases your body's ability to fight infection

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • To prevent organ transplant rejection:
    • Adults—5 milligrams (mg) injected into a vein once a day.
    • Children less than 12 years of age—Dose is based on body weight and must be determined by your doctor.