Naltrexone (Oral Route)

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Depression, or history of or
• Mental illness, or history of—Use with caution. May make these conditions worse.

• Failed the naloxone challenge test (medical test to check your dependence to opioid medicine) or
• Opioid withdrawal, acute or
• Positive urine test for opioids or
• Receiving opioid analgesics (eg, buprenorphine, methadone, morphine)—Should not be used in patients with these conditions.

• Kidney disease or
• Liver disease (including cirrhosis, hepatitis B or C)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.