Minocycline mucous membrane powder

Name: Minocycline mucous membrane powder

What is minocycline?

Minocycline is a tetracycline antibiotic that fights bacteria.

Minocycline mucous membrane powder is used together with certain dental procedures to treat periodontitis (gum disease). Periodontitis is an infection that causes inflammation in the gums around your teeth. This can cause the gums to pull away from the teeth, leaving deep pockets. Gum shrinkage can lead to tooth loss.

Minocycline powder may also be used for purposes not listed in this medication guide.

How is minocycline given?

You will receive this medicine in a dentist's office.

Minocycline powder is applied directly into the pockets between your gums and teeth. Your dentist will use a special device to place the medicine into these pockets.

For at least 1 week after treatment: You should not chew hard or crunchy foods such as carrots, or sticky foods such as hard candy, taffy, or gum.

For at least 10 days after treatment: You should not use dental floss or a dental pick.

Minocycline powder is only part of a complete treatment program that also includes good oral hygiene and routine dental care.

You may need to receive up to 3 treatments spaced 3 months apart. Follow your dentist's instructions very closely.

Replace your toothbrush with a new one every 3 or 4 months.

What happens if I overdose?

Since this medicine is given by a dentist in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving minocycline?

Avoid exposure to sunlight or tanning beds. Minocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid smoking, or consider quitting altogether. Smoking can increase your risk of further gum disease and tooth decay.

Minocycline dosing information

Usual Adult Dose for Periodontitis:

Adult periodontitis:
1 mg applied subgingivally by an oral health care professional into the base of the affected periodontal pocket. The quantity of 1 mg unit dose packets required for treatment varies with the depth, severity, and number of lesions. During clinical trials, up to 121 unit dose containers of minocycline topical were applied to a single patient during a single treatment session. Additionally, patients were treated in up to 3 sessions occurring at 3 month intervals.

For Healthcare Professionals

Applies to minocycline topical: mucous membrane insert


Minocycline topical powder is intended for local application only. Systemic effects from the absorption of small amounts of the drug are unlikely.[Ref]


Other side effects have included headache (9%) and pain (4.3%).[Ref]


Dermatologic side effects have included stomatitis (6.4%), mouth ulceration (5%), and mucous membrane disorder (3.3%).[Ref]


Gastrointestinal side effects have included dyspepsia (4%).[Ref]


Local side effects have included periodontitis (16.3%), tooth disorder (12.3%), tooth caries (9.9%), dental pain (9.9%), gingivitis (9.2%), pharyngitis (4.3%), and dental infection (3.8%).[Ref]


Immunologic side effects have included flu syndrome (5%) and infection (7.6%).[Ref]

Some side effects of minocycline topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.