Meperidine-promethazine Oral Capsule

Name: Meperidine-promethazine Oral Capsule

Highlights for meperidine-promethazine

MEPERIDINE; PROMETHAZINE (me PER i deen; proe METH a zeen) is a pain reliever. It is used to treat moderate to severe pain.

This drug can cause serious side effects. See which side effects you should report to your doctor right away.

Know how to use your medication, and learn what might happen if you miss a dose.

Talk to your healthcare provider if you have any of these conditions.

Know what to watch for and get tips for reducing your risks while taking this drug.

Meperidine-promethazine Side Effects

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • confusion
  • seizures
  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
  • signs and symptoms of neuroleptic malignant syndrome (NMS) such as confusion; fast or irregular heartbeat; high fever; increased sweating; uncontrolled head, mouth, neck, arm, or leg movements; stiff muscles
  • trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • dry mouth
  • nausea, vomiting
  • tiredness

Meperidine-promethazine May Interact with Other Medications

Do not take this medicine with any of the following medications:

  • cisapride
  • dofetilide
  • dronedarone
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • metoclopramide
  • pimozide
  • procarbazine
  • quinidine
  • ritonavir
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • acyclovir
  • alcohol
  • antihistamines for allergy, cough and cold
  • certain medicines for anxiety or sleep
  • certain medicines for depression like amitriptyline, fluoxetine, sertraline
  • certain medicines for seizures like phenobarbital, primidone
  • cimetidine
  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol
  • linezolid
  • local anesthetics like lidocaine, pramoxine, tetracaine
  • medicines that relax muscles for surgery
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • other narcotic medicines for pain or cough
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine
  • risperidone
  • trimethobenzamide
  • valacyclovir
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

How to Use meperidine-promethazine

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • brain tumor
  • head injury
  • heart disease
  • kidney disease
  • liver disease
  • lung disease or breathing difficulties, including asthma
  • seizures
  • use within 14 days of a MAOI like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • an unusual or allergic reaction to meperidine or other opiate drugs, promethazine or other phenothiazines, lactose, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

The medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Where should I keep my medicine?

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

This medicine may cause accidental overdose and death if it taken by other adults, children, or pets. Mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.

Store at room temperature at 25 degrees C (77 degrees F).

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