Mepergan

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other opioid medicines, meperidine and promethazine can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

• noisy breathing, sighing, shallow breathing;
• a slow heart rate or weak pulse;
• severe weakness or drowsiness, feeling like you might pass out;
• confusion, hallucinations, feeling anxious or agitated;
• pounding heartbeats or fluttering in your chest;
• loss of balance or coordination;
• sudden ill feeling, fever, chills, sore throat, easy bruising or bleeding;
• vision problems; or
• severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

• dizziness, drowsiness;
• nausea, vomiting, constipation,
• dry mouth;
• flushing (warmth, redness, or tingly feeling); or
• sweating.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.