Ivermax Plus Injection

1% w/v ivermectin and 10% w/v clorsulon in a sterile solution

ANADA 200-436         Approved by the FDA

For the effective treatment and control of internal parasites, including adult liver flukes, and external parasites.

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

The ability of ivermectin to deliver internal and external parasite control has been proven in cattle markets around the world. Now, IVERMAX® PLUS Injection for Cattle combines ivermectin with clorsulon, an effective adult flukicide.

A single injection of IVERMAX® PLUS Injection for Cattle (ivermectin and clorsulon) offers all the benefits of an ivermectin injection plus control of adult Fasciola hepatica.

The dosage level of clorsulon supplied by IVERMAX® PLUS Injection for Cattle is effective only against adult liver flukes (Fasciola hepatica).

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.

Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Clorsulon is rapidly absorbed into the circulating blood. Erythrocytes with bound drug as well as plasma are ingested by Fasciola hepatica. Adult Fasciola hepatica are killed by clorsulon because of inhibition of enzymes in the glycolytic pathway, which is their primary source of energy.

Transitory discomfort has been observed in some cattle following subcutaneous administration. Soft-tissue swelling at the injection site has also been observed. These reactions have disappeared without treatment. Divide doses greater than 10 mL between two injection sites to reduce occasional discomfort or site reaction. Different injection sites should be used for other parenteral products.

IVERMAX®PLUS Injection for Cattle has been developed specifically for use in cattle only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

For subcutaneous injection in cattle only.

This product is not for intravenous or intramuscular use.

When to Treat Cattle with Grubs

IVERMAX® PLUS Injection for Cattle effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season. Destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host-parasite reactions including the possibility of fatalities. Killing Hypoderma lineatum when it is in the tissue surrounding the esophagus (gullet) may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis. These reactions are not specific to treatment with IVERMAX®PLUS Injection for Cattle, but can occur with any successful treatment of grubs. Cattle should be treated either before or after these stages of grub development. Consult your veterinarian concerning the proper time for treatment.

Cattle treated with IVERMAX®PLUS Injection for Cattle after the end of the heel fly season may be retreated with ivermectin during the winter for internal parasites, mange mites, or sucking lice, without danger of grub-related reactions. A planned parasite control program is recommended.

IVERMAX®PLUS Injection for Cattle Injection is available in five ready-to-use pack sizes:

The 50 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 10 head of 550 lb (250 kg) cattle.

The 100 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 20 head of 550 lb (250 kg) cattle.

The 250 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 50 head of 550 lb (250 kg) cattle.

The 500 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 100 head of 550 lb (250 kg) cattle.

The 1000 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 200 head of 550 lb (250 kg) cattle.

Restricted Drug - California. Use Only as Directed.

IVERMAX® is a trademark of RXV Products®

Made in the UK.

Manufactured by:                                      Manufactured for:
Norbrook Laboratories Limited                RXV Products®
Newry, Co. Down, Northern Ireland       Westlake, TX 76262

RXV®
002448I02

ivermax®

PLUS+

Injection for Cattle

1% w/v ivermectin and 10% w/v clorsulon in a sterile solution

ANADA 200-436,

Approved by the FDA

NET CONTENTS: 1000 mL

Consult your veterinarian for assistance in the

Diagnosis, treatment and control of parasitism.