Iodoquinol topical

Contraindications

• Known hypersensitivity to iodoquinol or any ingredient in the formulation.a b c d e f

• Iodine intolerance.a

Warnings/Precautions

Sensitivity Reactions

Cross-sensitivity may occur between halogenated hydroxyquinolines (e.g., clioquinol).a

General Precautions

Possible local irritation (e.g., burning, itching, irritation, dryness).b c d e f If irritation occurs, discontinue the drug and institute appropriate therapy.a b c d e f

May stain skin and fabrics.108 b c d e f

Possible overgrowth of nonsusceptible organisms with prolonged therapy.108 b c d e f Institute appropriate therapy if superinfection occurs.108 c d e f

Adverse systemic effects may occur when fixed-combination preparation also containing hydrocortisone is used on large areas of the body or with occlusive dressing.b c d e f

Children may be more susceptible to adverse systemic effects.b c d e f (See Use of Fixed Combinations and also Pediatric Use, under Cautions.)

When used topically in fixed combination with hydrocortisone, consider the usual cautions, precautions, and contraindications associated with topical corticosteroid therapy.108 b c d e f

Specific Populations

Category C.b c d e f g

Not known if distributed into milk.b c d e f Use caution in nursing women.b c d e f

Safety and efficacy not established in children <12 years of age.108 b c d e f

Use in pediatric patients currently is not recommended given the association between oculotoxic/neurotoxic effects (e.g., optic neuritis, optic atrophy, subacute myelo-optic neuropathy [SMON]) and oral therapy with halogenated hydroxyquinoline derivatives100 101 104 109 114 115 116 117 118 119 120 121 122 123 124 125 and the availability of effective alternative topical anti-infectives.104 114

Clinical studies of fixed-combination iodoquinol and hydrocortisone cream did not include sufficient number of patients ≥65 years of age to determine whether geriatric patients respond differently than younger patients.c Other reported clinical experience has not identified differences in responses between geriatric patients and younger patients.c

Common Adverse Effects

Burning, itching, irritation, dry skin.b c d e f

Specific Tests

Absorption

Bioavailability

Percutaneous absorption of iodoquinol not known.108 b c d e f However, other halogenated hydroxyquinoline derivates (e.g., chlorquinaldol, clioquinol) are absorbed systemically following topical application to the skin.100 101 102 103 104 105 106 107

Distribution

Extent

Not known if distributed into milk.b c d e f

Elimination

Metabolism

Following oral administration, 3–5% of the dose is recovered in urine as a glucuronide.b c d e f

Storage

Topical

Fixed - combination with hydrocortisone: Tightly closed containers at room temperature.b e

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name