Ibuprofen and famotidine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ibuprofen and famotidine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ibuprofen and famotidine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen and famotidine combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ibuprofen and famotidine combination in the elderly. However, elderly patients are more likely to have age-related heart, stomach, or kidney problems, which may require caution and an adjustment in the dose for patients receiving ibuprofen and famotidine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ibuprofen and famotidine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ibuprofen and famotidine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amifampridine
• Amisulpride
• Bepridil
• Cisapride
• Dronedarone
• Ketorolac
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using ibuprofen and famotidine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab
• Aceclofenac
• Acemetacin
• Acenocoumarol
• Amiloride
• Amineptine
• Amiodarone
• Amitriptyline
• Amitriptylinoxide
• Amoxapine
• Amprenavir
• Amtolmetin Guacil
• Anagrelide
• Apixaban
• Ardeparin
• Argatroban
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Aspirin
• Atazanavir
• Balsalazide
• Bemiparin
• Bendroflumethiazide
• Benzthiazide
• Betamethasone
• Betrixaban
• Bismuth Subsalicylate
• Bivalirudin
• Bromfenac
• Budesonide
• Bufexamac
• Bumetanide
• Bupropion
• Buserelin
• Cangrelor
• Celecoxib
• Certoparin
• Chlorothiazide
• Chlorthalidone
• Choline Magnesium Trisalicylate
• Choline Salicylate
• Cilostazol
• Citalopram
• Clarithromycin
• Clomipramine
• Clonixin
• Clopamide
• Clopidogrel
• Clozapine
• Cortisone
• Crizotinib
• Cyclopenthiazide
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Dalteparin
• Danaparoid
• Dasatinib
• Deflazacort
• Degarelix
• Delamanid
• Delavirdine
• Desipramine
• Desirudin
• Deslorelin
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexamethasone
• Dexibuprofen
• Dexketoprofen
• Diazoxide
• Dibenzepin
• Diclofenac
• Diflunisal
• Digoxin
• Dipyridamole
• Dipyrone
• Domperidone
• Donepezil
• Dothiepin
• Doxepin
• Droxicam
• Duloxetine
• Edoxaban
• Efavirenz
• Enoxaparin
• Eplerenone
• Epoprostenol
• Eptifibatide
• Erlotinib
• Escitalopram
• Ethacrynic Acid
• Etodolac
• Etofenamate
• Etoricoxib
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Feverfew
• Floctafenine
• Fluconazole
• Flufenamic Acid
• Fluocortolone
• Fluoxetine
• Flurbiprofen
• Fluvoxamine
• Fondaparinux
• Fosamprenavir
• Foscarnet
• Furosemide
• Gefitinib
• Ginkgo
• Gonadorelin
• Goserelin
• Gossypol
• Heparin
• Histrelin
• Hydrochlorothiazide
• Hydrocortisone
• Hydroflumethiazide
• Hydroxychloroquine
• Hydroxyzine
• Ibuprofen
• Iloprost
• Imipramine
• Indapamide
• Indomethacin
• Ivabradine
• Ketoconazole
• Ketoprofen
• Ledipasvir
• Lepirudin
• Leuprolide
• Levofloxacin
• Levomilnacipran
• Lithium
• Lofepramine
• Lornoxicam
• Loxoprofen
• Lumiracoxib
• Magnesium Salicylate
• Meadowsweet
• Meclofenamate
• Mefenamic Acid
• Melitracen
• Meloxicam
• Mesalamine
• Methadone
• Methotrexate
• Methyclothiazide
• Methylprednisolone
• Metolazone
• Metronidazole
• Milnacipran
• Morniflumate
• Moxifloxacin
• Nabumetone
• Nadroparin
• Nafarelin
• Naproxen
• Nefazodone
• Nepafenac
• Niflumic Acid
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Nortriptyline
• Olsalazine
• Ondansetron
• Opipramol
• Oxaprozin
• Oxyphenbutazone
• Panobinostat
• Paramethasone
• Parecoxib
• Parnaparin
• Paroxetine
• Pasireotide
• Pazopanib
• Pemetrexed
• Pentosan Polysulfate Sodium
• Pentoxifylline
• Phenindione
• Phenprocoumon
• Phenylbutazone
• Phenyl Salicylate
• Piketoprofen
• Pimavanserin
• Piroxicam
• Pitolisant
• Polythiazide
• Posaconazole
• Pralatrexate
• Prasugrel
• Prednisolone
• Prednisone
• Proglumetacin
• Propyphenazone
• Proquazone
• Protein C
• Protriptyline
• Quetiapine
• Reboxetine
• Reviparin
• Ribociclib
• Rilpivirine
• Rivaroxaban
• Rofecoxib
• Salicylamide
• Salicylic Acid
• Salsalate
• Sertraline
• Sevoflurane
• Sibutramine
• Sodium Salicylate
• Sotalol
• Spironolactone
• Sulfasalazine
• Sulindac
• Sulpiride
• Tacrolimus
• Tenoxicam
• Tianeptine
• Tiaprofenic Acid
• Ticagrelor
• Ticlopidine
• Tinzaparin
• Tirofiban
• Tizanidine
• Tolazoline
• Tolfenamic Acid
• Tolmetin
• Torsemide
• Treprostinil
• Triamterene
• Trichlormethiazide
• Trimipramine
• Triptorelin
• Trolamine Salicylate
• Valdecoxib
• Vandetanib
• Vemurafenib
• Venlafaxine
• Vilazodone
• Vinflunine
• Vismodegib
• Vorapaxar
• Vortioxetine
• Warfarin
• Xipamide
• Zuclopenthixol

Using ibuprofen and famotidine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol
• Alacepril
• Amikacin
• Atenolol
• Azilsartan
• Azilsartan Medoxomil
• Benazepril
• Betaxolol
• Bisoprolol
• Candesartan
• Captopril
• Carteolol
• Carvedilol
• Cefditoren Pivoxil
• Cefpodoxime Proxetil
• Celiprolol
• Cilazapril
• Cyclosporine
• Delapril
• Enalapril
• Enalaprilat
• Eprosartan
• Esmolol
• Fosinopril
• Imidapril
• Irbesartan
• Labetalol
• Levobunolol
• Lisinopril
• Losartan
• Metipranolol
• Metoprolol
• Moexipril
• Nadolol
• Nebivolol
• Olmesartan
• Oxprenolol
• Penbutolol
• Pentopril
• Perindopril
• Pindolol
• Practolol
• Propranolol
• Quinapril
• Ramipril
• Sotalol
• Spirapril
• Telmisartan
• Temocapril
• Timolol
• Trandolapril
• Valsartan
• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of ibuprofen and famotidine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or
• Bleeding problems or
• Congestive heart failure or
• Crohn's disease, history of or
• Dehydration or
• Edema (fluid retention or swelling) or
• Heart attack, recent or history of or
• Heart or blood vessel disease or
• Hyperkalemia (high potassium in the blood) or
• Hypertension (high blood pressure) or
• Hypovolemia (low amount of blood) or
• Liver disease or
• Stomach ulcers or bleeding, history of or
• Stroke, history of or
• Systemic lupus erythematosus (autoimmune disease) or
• Ulcerative colitis, history of—Use with caution. May make these conditions worse.

• Aspirin-sensitive asthma or
• Aspirin sensitivity, history of or
• Kidney disease, severe—Should not be used in patients with these conditions.

• Heart surgery (eg, coronary artery bypass graft [CABG])—Should not be used to relieve pain right before or after the surgery.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of famotidine from the body.

• Tell all of your health care providers that you take ibuprofen and famotidine. This includes your doctors, nurses, pharmacists, and dentists.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Have your blood work checked if you are on this medicine for a long time. Talk with your doctor.
• High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
• Talk with your doctor before you drink alcohol.
• If you smoke, talk with your doctor.
• If you have asthma, talk with your doctor. You may be more sensitive to ibuprofen and famotidine.
• The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.
• The chance of heart attack and heart-related death is raised in people taking drugs like this one after a recent heart attack. People taking drugs like this one after a first heart attack were also more likely to die in the year after the heart attack compared with people not taking drugs like this one. Talk with the doctor.
• If you are taking aspirin to help prevent a heart attack, talk with your doctor.
• This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking this medicine with your other drugs.
• Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call the doctor right away if your child has signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• This medicine may raise the chance of a very bad brain problem called aseptic meningitis. Call your doctor right away if you have a headache, fever, chills, very upset stomach or throwing up, stiff neck, rash, bright lights bother your eyes, feeling sleepy, or feeling confused.
• If you are 65 or older, use ibuprofen and famotidine with care. You could have more side effects.
• NSAIDs like this medicine may affect egg release (ovulation) in women. This may cause you to not be able to get pregnant. This goes back to normal when ibuprofen and famotidine is stopped. Talk with your doctor.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this medicine, call your doctor right away.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Use ibuprofen and famotidine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food. Take with food if it causes an upset stomach.
• Swallow whole. Do not chew, break, or crush.
• Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
• Do not take this medicine for longer than you were told by your doctor.
• To gain the most benefit, do not miss doses.
• Keep using ibuprofen and famotidine as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Duexis

Osteoarthritis, rheumatoid arthritis: Relief of signs and symptoms of osteoarthritis and rheumatoid arthritis (RA) and to decrease the risk of developing upper GI ulcers

Hypersensitivity (eg, anaphylactic reactions, serious skin reactions) to ibuprofen, famotidine, or any component of the formulation or to other H2-receptor antagonists; history of asthma, urticaria, or allergic-type reaction to aspirin or other NSAIDs; use in the setting of coronary artery bypass graft (CABG) surgery

There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied).

Oral: Administer with or without food. Tablets should be swallowed whole and should not be cut to supply a lower dose; do not chew, crush, or divide.