Hydroxocobalamin injection

Since hydroxocobalamin is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.

You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with hydroxocobalamin. This rash should go away without treatment. Call your doctor if you have a rash that lasts longer than 4 weeks.

Call your doctor at once if you have a serious side effect such as:

• bright red blood in your stools;

• chest pain, fast or uneven heart rate;

• severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus;

• swelling in your feet or ankles;

• a light-headed feeling, like you might pass out; or

• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

• nausea;

• headache;

• acne, skin rash or redness;

• red coloring of your urine (may last 2 to 5 weeks); or

• pain, swelling, or irritation of your skin where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• It is used to treat anemia.
• It is used to treat or prevent low vitamin B12.
• It may be given to you for other reasons. Talk with the doctor.

• Tell all of your health care providers that you take hydroxocobalamin injection. This includes your doctors, nurses, pharmacists, and dentists.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
• If you are on dialysis, talk with your doctor.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using hydroxocobalamin injection while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

1000 mcg IM

Uncomplicated disease:
Initial dose: 30 mcg IM once daily for 5 to 10 days, or 100 mcg IM once daily for one week, followed by 100 mcg IM every other day for 2 weeks.
Maintenance dose: 100 to 200 mcg IM once a month

Complicated disease:
Initial dose: 1000 mcg IM once with folic acid 15 mg, followed by 100 mcg once daily with folic acid 5 mg daily for 1 week
Maintenance dose: 100 to 200 mcg IM once a month

Neonates: 1000 mcg IM twice a week

Uncomplicated disease:
Initial dose: 100 mcg IM daily for 10 to 15 days for a total dose of 1 to 5 mg, then maintenance of 60 mcg/month;

or 30 to 50 mcg/day for at least two weeks for a total dose of 1 to 5 mg, then maintenance of 100 mcg/month.

Data not available