Evolocumab (Subcutaneous Route)

Name: Evolocumab (Subcutaneous Route)

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of evolocumab injection in the pediatric population. Safety and efficacy have not been established in children younger than 13 years of age with HoFH, and in children with primary hyperlipidemia.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of evolocumab injection in the elderly.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For primary hyperlipidemia:
      • Adults—140 milligrams (mg) injected under your skin every 2 weeks, or 420 mg injected under your skin once a month.
      • Children—Use and dose must be determined by your doctor.
    • For homozygous familial hypercholesterolemia:
      • Adults and children 13 years of age and older—420 milligrams (mg) injected under your skin once a month.
      • Children younger than 13 years of age—Use and dose must be determined by your doctor.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also keep the medicine in the original carton at room temperature for 30 days. Throw away any unused medicine within 30 days.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

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