Ethacrynate sodium Intravenous

Name: Ethacrynate sodium Intravenous

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Uses For ethacrynate sodium

Ethacrynate sodium injection belongs to a group of medicines called loop diuretics or "water pills." Ethacrynate sodium is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

ethacrynate sodium is available only with your doctor's prescription .

Before Using ethacrynate sodium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ethacrynate sodium, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ethacrynate sodium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ethacrynate sodium injection in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ethacrynate sodium injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dosage in patients receiving ethacrynate sodium injection .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving ethacrynate sodium, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ethacrynate sodium with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Desmopressin

Using ethacrynate sodium with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac
Acemetacin
Amikacin
Amtolmetin Guacil
Arsenic Trioxide
Aspirin
Bepridil
Bromfenac
Bufexamac
Celecoxib
Choline Salicylate
Clonixin
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Digitoxin
Dipyrone
Dofetilide
Droperidol
Droxicam
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Flufenamic Acid
Flurbiprofen
Foscarnet
Furosemide
Gentamicin
Ibuprofen
Indomethacin
Kanamycin
Ketanserin
Ketoprofen
Ketorolac
Levomethadyl
Lithium
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Metolazone
Morniflumate
Nabumetone
Naproxen
Neomycin
Nepafenac
Netilmicin
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Oxaprozin
Oxyphenbutazone
Parecoxib
Phenylbutazone
Piketoprofen
Piroxicam
Proglumetacin
Propyphenazone
Proquazone
Rofecoxib
Salicylic Acid
Salsalate
Sodium Salicylate
Sotalol
Streptomycin
Sulindac
Tenoxicam
Tiaprofenic Acid
Tobramycin
Tolfenamic Acid
Tolmetin
Valdecoxib

Using ethacrynate sodium with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alacepril
Benazepril
Captopril
Cilazapril
Cortisone
Delapril
Enalapril
Enalaprilat
Fosinopril
Germanium
Ginseng
Gossypol
Imidapril
Licorice
Lisinopril
Moexipril
Pentopril
Perindopril
Quinapril
Ramipril
Spirapril
Temocapril
Trandolapril
Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Precautions While Using ethacrynate sodium

Your doctor will only give you a few doses of ethacrynate sodium until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .

ethacrynate sodium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

Bleeding gums
bloating
clay-colored stools
constipation
darkened urine
indigestion
itching
large, flat, blue or purplish patches in the skin
loss of appetite
nausea
painful knees and ankles
pains in stomach, side, or abdomen, possibly radiating to the back
pinpoint red spots on skin
raised red swellings on the skin, the buttocks, legs, or ankles
skin rash
unpleasant breath odor
vomiting of blood
yellow eyes or skin

Incidence not determined

Anxiety
black, tarry stools
blood in urine
blurred vision
cold sweats
coma
confusion
convulsions (seizures)
cool, pale skin
cough or hoarseness
depression
dizziness
dry mouth
fast heartbeat
fever with or without chills
flushed, dry skin
fruit-like breath odor
general feeling of tiredness or weakness
headache
increased hunger
increased thirst
increased urination
joint pain, stiffness, or swelling
lower back, side, or stomach pain
nausea
nervousness
nightmares
painful or difficult urination
pale skin
shakiness
shortness of breath
slurred speech
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sweating
swelling of the feet or lower legs
troubled breathing
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
watery and severe diarrhea

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Confusion
decreased urination
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
increase in heart rate
irregular heartbeat
muscle cramps or pain
numbness, tingling, pain, or weakness in the hands or feet
rapid breathing
sunken eyes
thirst
trembling
weakness and heaviness of the legs
wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined

Continuing ringing or buzzing or other unexplained noise in ears
difficulty swallowing
fear
feeling of constant movement of self or surroundings
feeling of fullness in the ears
general feeling of discomfort or illness
hearing loss
irritation, or pain at injection site
mild diarrhea
sensation of spinning
stomach soreness or discomfort
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions

Before using ethacrynate sodium, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: gout, kidney disease, liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

This drug can lower certain salt/mineral levels (such as sodium, potassium) in your blood. Your doctor may tell you to use more salt, eat potassium-rich foods (such as bananas, orange juice), or take a potassium supplement. Ask your doctor for more details.

This medication may affect your blood sugar. If you have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and water/mineral loss.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Lab and/or medical tests (such as kidney tests, blood mineral levels such as potassium) should be done while you are taking this medication. Keep all medical and lab appointments.

Missed Dose

Not applicable.