Eqvalan

Oral:

Serious side effects have been reported with this medication, and certain precautions should be followed:

• fever
• blistering or peeling skin
• rash
• hives
• itching

If treating specifically for the parasite loa loa (endemic in West or Central Africa), you may also experience certain serious adverse effects that should be addressed immediately if they occur. These effects have been seen very rarely following the use of ivermectin.

• swelling of the eyes, face, arms, hands, feet, ankles, or lower legs
• joint pain and swelling
• painful and swollen glands of the neck, armpit or groin
• rapid heartbeat
• eye pain, redness, or tearing
• swelling of the eye or eyelids
• abnormal sensation in the eyes

Do not use ivermectin tablets if you are allergic to any of its ingredients.

Ivermectin tablets can cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Do not drive or operate heavy machinery until you know how this medication affects you.

Topical:

 Certain precautions should be followed when using ivermectin lotion:

• Ivermectin lotion is for use on scalp hair and scalp only. Do not get ivermectin lotion in your eyes, mouth, or vagina.

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of ivermectin lotion and tablets, there are no specific foods that you must exclude from your diet.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Oral:

For the treatment of strongyloidiasis (threadworm):

For the treatment of onchocerciasis (river blindness):

Topical:

• Apply ivermectin lotion to dry hair in an amount sufficient (up to 1 tube) to thoroughly coat the hair and scalp.

This syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight.

(1) While holding plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide it so the side nearest the barrel is at the prescribed weight marking. (2) Lock the ring in place by making a 1/4 turn to the right. (3) Make sure that the horse's mouth contains no feed. (4) Remove the cover from the tip of the syringe. (5) Insert the syringe tip into the horse's mouth at the space between the teeth. (6) Depress the plunger as far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse's head for a few seconds after dosing.

All horses should be included in a regular parasite control program with particular attention being paid to mares, foals and yearlings. Foals should be treated initially at 6 to 8 weeks of age, and routine treatment repeated as appropriate. Consult your veterinarian for a control program to meet your specific needs. Eqvalan (ivermectin) Paste effectively controls gastrointestinal nematodes and bots of horses. Regular treatment will reduce the chances of verminous arteritis caused by Strongylus vulgaris.

Broad-spectrum Control – Eqvalan Paste kills important internal parasites, including bots and the arterial stages of S. vulgaris, with a single dose. Eqvalan Paste is a potent antiparasitic agent that is neither a benzimidazole nor an organophosphate.

Swelling and itching reactions after treatment with Eqvalan (ivermectin) Paste have occurred in horses carrying heavy infections of neck threadworm (Onchocerca sp. microfilariae). These reactions were most likely the result of microfilariae dying in large numbers. Symptomatic treatment may be advisable. Consult your veterinarian should any such reactions occur. Healing of summer sores involving extensive tissue changes may require other appropriate therapy in conjunction with treatment with Eqvalan (ivermectin) Paste. Reinfection, and measures for its prevention, should also be considered. Consult your veterinarian if the condition does not improve.

Manufactured by: Merial Saúde Animal Ltda., Paulinia, São Paulo, CEP 13140-970, Brazil

Manufactured for: Merial Limited, Operational Headquarters, 3239 Satellite Blvd., Duluth, GA 30096-4640, U.S.A.

U.S. Pat. 4,199,569

Eqvalan is a registered trademark of Merial Limited.

Copyright ©2008 Merial Limited. All rights reserved.

05/2008

Product 25874
For Oral Use in Horses Only

Eqvalan®
(ivermectin)
Paste 1.87%

Anthelmintic and Boticide

For Treatment of Large Strongyles, Small Strongyles,
Pinworms, Roundworms (Ascarids), Hairworms, Neck
Threadworms, Large-mouth Stomach Worms, Bots. See
carton or attached labeling for complete indications and
use directions. Consult your veterinarian for assistance in
the diagnosis, treatment, and control of parasitism.

NADA 134-314, Approved by the FDA

NET WT. 0.21 oz (6.08 g)
U.S. Pat. 4,199,569